Department of Physiology, Basic Medical Sciences Institute, Jinnah Post graduate Medical Centre , Karachi , Pakistan.
Department of Family, Medicine Aga Khan University , Karachi , Pakistan.
Arch Physiol Biochem. 2019 Dec;125(5):441-446. doi: 10.1080/13813455.2018.1481095. Epub 2018 Jun 18.
The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed. High TIMP2 was seen in MetS group (145.28 ± 23.11 pg/ml) versus controls (19.06 ± 1.19 pg/ml; < .001). Serum cholesterol, triglyceride, LDL-c and glucose levels were significantly higher in MetS subjects ( < .05). MetS individuals (72.72%) showed positive fatty liver changes versus 14.5% controls. Elevated TIMP2 positively correlated with waist circumference, body fat, blood glucose and NAFLD. Furthermore, every unit rise in waist circumference and TIMP2 and a unit decrease in HDL were associated with higher odds of developing NAFLD ( < .05). There may be concurrent relationship between TIMP2 and NAFLD in MetS that requires further evaluation to improve risk assessment and early diagnosis of MetS.
本病例对照研究旨在评估代谢综合征（MetS）患者和无代谢综合征患者的 TIMP2 水平，并将其与非酒精性脂肪肝变化（NAFLD）相关联。共招募了 33 名 MetS 患者和 55 名对照者。进行了人体测量学数据、血脂和血糖谱、TIMP2 和肝脏超声检查。MetS 组的 TIMP2 水平较高（145.28±23.11pg/ml），而对照组为 19.06±1.19pg/ml（ < .001）。MetS 患者的血清胆固醇、甘油三酯、LDL-c 和血糖水平显著升高（ < .05）。MetS 患者（72.72%）的脂肪肝变化呈阳性，而对照组为 14.5%。升高的 TIMP2 与腰围、体脂、血糖和 NAFLD 呈正相关。此外，腰围和 TIMP2 每增加一个单位，HDL 减少一个单位，与发生 NAFLD 的几率增加相关（ < .05）。TIMP2 和 MetS 中的 NAFLD 之间可能存在并发关系，需要进一步评估以改善 MetS 的风险评估和早期诊断。
