Department of Toxicology, Guilin Medical University School of Public Health, Guilin, China.
The Library and Information Center, China Pharmaceutical University, Nanjing, China.
PLoS One. 2018 Jun 18;13(6):e0198813. doi: 10.1371/journal.pone.0198813. eCollection 2018.
This study investigated the association of PM2.5 exposure with VEGF by conducting a systematic review of existing literature and performing a meta-analysis. We searched all the studies published in the Cochrane Library, PUBMED, Embase, China National Knowledge Infrastructure China National Knowledge Infrastructure, and WanFang Electronic Database before June 2017. Finally six studies were identified. It confirmed that the increase in VEGF (β = 1.23 pg/ml, 95% CI: 0.45, 2.01) was significantly associated with the PM2.5 mass concentration of 10 μg/m3. Studies from Canada showed that PM2.5 exposure statistically elevated the level of VEGF level that an increase of 1.20 pg/ml (95% CI: 0.88, 1.52) in VEGF was associated with per 10 μg/m3 increase in PM2.5 concentration. Other subgroup analyses indicated that the effects of PM2.5 exposure on VEGF differed per the in different exposure assessment methods, study designs, and study settings. It was concluded that elevated VEGF levels was significantly positive associated with PM2.5 exposure. Exposure assessment methods and study countries were the major sources of heterogeneity among studies.
本研究通过对现有文献进行系统回顾和荟萃分析，探讨了 PM2.5 暴露与 VEGF 的相关性。我们检索了 2017 年 6 月之前在 Cochrane 图书馆、PUBMED、Embase、中国知网和万方数据库发表的所有研究。最终确定了 6 项研究。结果证实，VEGF（β=1.23pg/ml，95%CI：0.45，2.01）的增加与 PM2.5 质量浓度为 10μg/m3 显著相关。来自加拿大的研究表明，PM2.5 暴露使 VEGF 水平统计学上升高，每增加 10μg/m3 的 PM2.5 浓度，VEGF 水平增加 1.20pg/ml（95%CI：0.88，1.52）。其他亚组分析表明，PM2.5 暴露对 VEGF 的影响因暴露评估方法、研究设计和研究地点的不同而不同。结果表明，VEGF 水平的升高与 PM2.5 暴露呈显著正相关。暴露评估方法和研究国家是研究间异质性的主要来源。
