培养的乳腺癌细胞中的转铁蛋白受体
Transferrin receptors in cultured breast cancer cells.
作者信息
Vandewalle B, Granier A M, Peyrat J P, Bonneterre J, Lefebvre J
出版信息
J Cancer Res Clin Oncol. 1985;110(1):71-6. doi: 10.1007/BF00402505.
Abstract
Transferrin receptors were demonstrated on the cell membrane of breast cancer epithelial cells in primary or long-term culture. Diferric transferrin binding was saturable, specific and was not related to DNA content or clinical and histological features of the tumour. However a good correlation (p less than 0.01) was found between transferrin binding and thymidine incorporation. These results suggest the possibility of transferrin receptor measurement as a reflection of the proliferative activity of cultured breast tumour cells.
摘要
在原代培养或长期培养的乳腺癌上皮细胞膜上证实有转铁蛋白受体。双铁转铁蛋白结合具有饱和性、特异性，且与肿瘤的DNA含量、临床及组织学特征无关。然而，发现转铁蛋白结合与胸腺嘧啶核苷掺入之间存在良好的相关性（p小于0.01）。这些结果提示测定转铁蛋白受体有可能反映培养的乳腺肿瘤细胞的增殖活性。
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