2017 年国际异种移植学会主席演讲：异种移植的最新进展。
The 2017 IXA Presidential Lecture: Recent developments in xenotransplantation.
机构信息
Immunology Research Centre, St Vincent's Hospital Melbourne, Department of Medicine, University of Melbourne, Melbourne, Vic., Australia.
出版信息
Xenotransplantation. 2018 May;25(3):e12416. doi: 10.1111/xen.12416.
The last few years have seen significant progress in xenotransplantation. Porcine xenograft survival in preclinical models continues to improve, accompanied by the adjustment of immunosuppression to more clinically realistic levels. The rapid uptake of CRISPR/Cas9 technology has accelerated the generation of new knock-in and knockout pigs, including animals null for the endogenous retrovirus PERV. This brief review presents a personal view of recent developments in the field.
最近几年，异种移植领域取得了显著的进展。猪异种移植物在临床前模型中的存活率持续提高，同时免疫抑制的调整也更加符合临床实际水平。CRISPR/Cas9 技术的快速应用加速了新型敲入和敲除猪的产生，包括内源性逆转录病毒 PERV 缺失的动物。本文简要介绍了该领域的最新进展。
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