局部递送达马受体激动剂以促进骨再生和缺损愈合。

Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing.

机构信息

Hansjörg Wyss Department of Plastic Surgery at New York University School of Medicine, 307 East 33rd Street, New York, NY 10016, United States; Division of Translational Medicine at New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States; Department of Biomaterials & Biomimetics at New York University College of Dentistry, 433 First Avenue, New York, NY 10010, United States; Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, United States.

Hansjörg Wyss Department of Plastic Surgery at New York University School of Medicine, 307 East 33rd Street, New York, NY 10016, United States.

出版信息

Adv Drug Deliv Rev. 2019 Jun;146:240-247. doi: 10.1016/j.addr.2018.06.010. Epub 2018 Jun 18.

DOI:10.1016/j.addr.2018.06.010

PMID:29913176

Abstract

Adenosine receptor activation has been investigated as a potential therapeutic approach to heal bone. Bone has enhanced regenerative potential when influenced by either direct or indirect adenosine receptor agonism. As investigators continue to elucidate how adenosine influences bone cell homeostasis at the cellular and molecular levels, a small but growing body of literature has reported successful in vivo applications of adenosine delivery. This review summarizes the role adenosine receptor ligation plays in osteoblast and osteoclast biology and remodeling/regeneration. It also reports on all the modalities described in the literature at this point for delivery of adenosine through in vivo models for bone healing and regeneration.

摘要

腺苷受体激活已被研究作为一种潜在的治疗方法来治疗骨骼。当直接或间接的腺苷受体激动作用于骨骼时，骨骼具有增强的再生潜力。随着研究人员继续阐明腺苷如何在细胞和分子水平上影响骨细胞的动态平衡，越来越多的文献报道了腺苷传递的成功体内应用。这篇综述总结了腺苷受体配体在成骨细胞和破骨细胞生物学以及重塑/再生中的作用。它还报告了目前文献中描述的所有通过体内模型用于骨愈合和再生的腺苷传递方式。