Larson S M, Di Chiro G
J Comput Assist Tomogr. 1985 Jul-Aug;9(4):676-81. doi: 10.1097/00004728-198507010-00003.
Regional specialization of two types of neuroreceptor--opiate and dopamine--was mapped by positron emission tomography (PET) in the subcortical gray matter of the living baboon and analyzed in comparison with glucose metabolism. The three radiopharmaceuticals used--[18F]3-acetylcyclofoxy, [11C]3-N-methylspiperone, and [18F]2-fluoro-2-deoxyglucose--traced opiate- and dopamine-receptor distribution and regional glucose metabolism, respectively. A combination of high spatial resolution (6-7 mm) and the intrinsic sensitivity of the PET method made possible the detection of nanomolar concentrations of neuroreceptors and micromolar concentrations of metabolized glucose, with different and distinctive anatomo-functional distributions in thalami and basal ganglia.
通过正电子发射断层扫描（PET）对活体狒狒皮质下灰质中两种神经受体——阿片受体和多巴胺受体——的区域特化进行了图谱绘制，并与葡萄糖代谢进行了比较分析。所使用的三种放射性药物——[18F]3-乙酰环磷酰氧、[11C]3-N-甲基螺哌隆和[18F]2-氟-2-脱氧葡萄糖——分别追踪阿片受体和多巴胺受体的分布以及区域葡萄糖代谢。高空间分辨率（6 - 7毫米）与PET方法的固有灵敏度相结合，使得检测纳摩尔浓度的神经受体和微摩尔浓度的代谢葡萄糖成为可能，在丘脑和基底神经节中呈现出不同且独特的解剖功能分布。
