Department of Plant Pathology/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China.
College of Plant Protection, China Agricultural University, Beijing 100193, China.
Molecules. 2018 Jun 15;23(6):1455. doi: 10.3390/molecules23061455.
is the pathogen of gray mold disease affecting a wide range of plant hosts, with consequential economic losses worldwide. The increased frequency of fungicide resistance of the pathogen challenges its disease management, and thus the development of alternative control strategies are urgently required. In this study, we showed excellent synergistic interactions between resveratrol and pyrimethanil. Significant synergistic values were recorded by the two-drug combination on the suppression of mycelial growth and conidia germination of . The combination of resveratrol and pyrimethanil caused malformation of mycelia. Moreover, the inoculation assay was conducted on table grape and consistent synergistic suppression of the two-drug combination was found in vivo. Our findings first revealed that the combination of resveratrol and pyrimethanil has synergistic effects against resistant and support the potential use of resveratrol as a promising adjuvant on the control of gray mold.
是一种广泛影响植物宿主的灰霉病病原体，给全世界造成了经济损失。该病原体对杀菌剂的抗性不断增加，给病害管理带来了挑战，因此迫切需要开发替代控制策略。在本研究中，我们发现白藜芦醇和嘧啶胺之间具有优异的协同作用。该两药组合对 的菌丝生长和孢子萌发具有显著的协同抑制作用，记录到显著的协同值。白藜芦醇和嘧啶胺的组合导致菌丝畸形。此外，在酿酒葡萄上进行接种试验，发现两药组合在体内具有协同抑制作用。我们的研究结果首次揭示了白藜芦醇和嘧啶胺联合使用对抗性 的协同作用，并支持将白藜芦醇作为一种有前途的助剂用于防治灰霉病。
