van der Heijden Gert-Jan, Wang Zhiyue J, Chu Zili D, Haymond Morey, Sauer Pieter J J, Sunehag Agneta L
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Children (Basel). 2018 Jun 15;5(6):79. doi: 10.3390/children5060079.
Hispanic adolescent girls with normal BMI frequently have high body fat %. Without knowledge of body fat content and distribution, their risk for metabolic complications is unknown. We measured metabolic risk indicators and abdominal fat distribution in post-pubertal Hispanic adolescent girls with Normal BMI (N-BMI: BMI < 85th percentile) and compared these indicators between girls with Normal BMI and High Fat content (N-BMI-HF: body fat ≥ 27%; = 15) and Normal BMI and Normal Fat content (N-BMI-NF: body fat < 27%; = 8). Plasma concentrations of glucose, insulin, adiponectin, leptin and Hs-CRP were determined. Insulin resistance was calculated using an oral glucose tolerance test. Body fat % was measured by DXA and subcutaneous, visceral and hepatic fat by MRI/MRS. The N-BMI-HF girls had increased abdominal and hepatic fat content and increased insulin resistance, plasma leptin and Hs-CRP concentrations ( < 0.05) as compared to their N-BMI-NF counterparts. In N-BMI girls, insulin resistance, plasma insulin and leptin correlated with BMI and body fat % ( < 0.05). This research confirms the necessity of the development of BMI and body fat % cut-off criteria per sex, age and racial/ethnic group based on metabolic risk factors to optimize the effectiveness of metabolic risk screening procedures.
体重指数（BMI）正常的西班牙裔青春期女孩往往体脂百分比很高。由于不清楚她们的体脂含量和分布情况，其发生代谢并发症的风险未知。我们测量了青春期后BMI正常（N-BMI：BMI低于第85百分位数）的西班牙裔青春期女孩的代谢风险指标和腹部脂肪分布，并比较了BMI正常且体脂含量高（N-BMI-HF：体脂≥27%；n = 15）和BMI正常且体脂含量正常（N-BMI-NF：体脂<27%；n = 8）的女孩之间的这些指标。测定了血浆葡萄糖、胰岛素、脂联素、瘦素和超敏C反应蛋白（Hs-CRP）的浓度。使用口服葡萄糖耐量试验计算胰岛素抵抗。通过双能X线吸收法（DXA）测量体脂百分比，通过磁共振成像/磁共振波谱（MRI/MRS）测量皮下、内脏和肝脏脂肪。与N-BMI-NF的女孩相比，N-BMI-HF的女孩腹部和肝脏脂肪含量增加，胰岛素抵抗、血浆瘦素和Hs-CRP浓度升高（P<0.05）。在BMI正常的女孩中，胰岛素抵抗、血浆胰岛素和瘦素与BMI和体脂百分比相关（P<0.05）。本研究证实，有必要根据代谢危险因素，针对不同性别、年龄和种族/族裔群体制定BMI和体脂百分比的截断标准，以优化代谢风险筛查程序的有效性。
