Student Research Committee, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran.
Department of Clinical Nutrition, School of Nutritional Scientists and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
BMC Endocr Disord. 2020 Nov 16;20(1):171. doi: 10.1186/s12902-020-00648-8.
Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.
Forty women with body mass index (BMI) = 18.5-24.9 kg/m and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured.
The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively.
It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.
正常体重肥胖（NWO）个体易患代谢综合征。本研究旨在探讨女性 NWO 患者循环中 vaspin、瘦素水平及其与血糖和血脂谱的关系。
将 40 名 BMI（体重指数）为 18.5-24.9kg/m²，体脂（FM）≥30%的女性分配到 NWO 组。将 30 名年龄匹配、BMI 相同且 FM<30%（正常体重非肥胖者；NWNO）的女性作为对照组。除了进行人体测量外，还测量了血糖和血脂谱以及瘦素和 vaspin 的循环水平。
NWO 组参与者的平均年龄为 28.76±4.76 岁，对照组为 29.23±4.50 岁。NWO 组的血清胰岛素（9.02±4.75 比 6.24±2.51，P=0.009）、瘦素（17.31±8.10 比 9.94±4.30，P<0.001）和稳态模型评估的胰岛素抵抗（HOMA-IR）（33.77±20.71 比 23.48±10.03，P=0.009）水平均高于 NWNO 组。与对照组相比，NWO 组的 vaspin 血清水平较高（分别为 34.82pg/ml 和 27.72pg/ml，P=0.12）。在 NWO 组中，瘦素水平与 FBS（r=0.45，P=0.02）、胰岛素（r=0.51，P=0.008）和 HOMA-IR（r=0.46，P=0.02）呈正相关，而 vaspin 浓度与胰岛素（r=0.36，P=0.02）和 HOMA-IR（r=0.30，P=0.06）呈正相关。
与 NWNO 相比，NWO 女性的胰岛素和 HOMA-IR 指数明显更高。NWO 组中较高的瘦素和 vaspin 浓度与血糖谱有关。
