Pharmacology Department, Faculty of Medicine, University of Monastir, Tunisia.
Pharmacogenomics. 2018 Jul 1;19(11):889-893. doi: 10.2217/pgs-2017-0200. Epub 2018 Jun 19.
Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. In this case, we have shown that the IL36RN gene mutation is not a constant condition in drug-induced AGEP. Clinicians should be aware of this side effect of codeine especially, in patients with a history of psoriasis. More studies are needed to clarify the association between drug-induced AGEP and IL36RN gene mutations.
最近的研究表明，IL-36RN 基因突变与脓疱性全身性疾病的发病有关。在文献中，仅报道了一例由 IL36RN 突变患者的可待因引起的急性泛发性发疹脓疱病（AGEP）病例。在此，我们报告了一例由可待因引起的 AGEP 病例，该患者有银屑病病史，并通过口服激发试验得到证实。在这种情况下，我们表明 IL36RN 基因突变并不是药物引起的 AGEP 的恒定状态。临床医生应特别注意可待因的这种副作用，尤其是在有银屑病病史的患者中。需要进一步研究阐明药物引起的 AGEP 与 IL36RN 基因突变之间的关联。
