DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Semin Immunol. 2018 Oct;39:73-80. doi: 10.1016/j.smim.2018.06.001. Epub 2018 Jun 18.
The development of an improved vaccine to stimulate an effective response against Mycobacterium tuberculosis (MTB) infection and disease will be a major breakthrough in the fight against TB. A lack of tools to adequately track the progression or resolution of events in TB pathogenesis that occur at bacterial loads below the threshold for culture in human samples seriously hampers vaccine development and evaluation. In this review we discuss recent studies that use new imaging applications, modalities and analysis techniques to provide insight into the dynamic processes of MTB infection and disease that are challenging to monitor. These include early infection, the spectrum of latency and subclinical disease, the paucibacillary state induced by treatment, and events leading to recurrence, including relapse.
开发一种改良的疫苗来刺激针对结核分枝杆菌（MTB）感染和疾病的有效反应将是抗击结核病的重大突破。缺乏足够的工具来跟踪人类样本中低于培养阈值的细菌负荷下发生的结核病发病机制中的进展或解决事件，严重阻碍了疫苗的开发和评估。在这篇综述中，我们讨论了最近使用新的成像应用、方式和分析技术的研究，这些研究深入了解了难以监测的 MTB 感染和疾病的动态过程。这些过程包括早期感染、潜伏和亚临床疾病的范围、治疗引起的少菌状态以及导致复发的事件，包括复发。
