Peña Juliet C, Ho Wen-Zhe
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Animal Biosafety Level III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, China Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Infect Immun. 2015 Mar;83(3):852-62. doi: 10.1128/IAI.02850-14. Epub 2014 Dec 29.
The use of animal models has been invaluable for studying the pathogenesis of Mycobacterium tuberculosis infection, as well as for testing the efficacy of vaccines and drug regimens for tuberculosis. Among the applied animal models, nonhuman primates, particularly macaques, share the greatest anatomical and physiological similarities with humans. As such, macaque models have been used for investigating tuberculosis pathogenesis and preclinical testing of drugs and vaccines. This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and may continue to advance the field of global tuberculosis research.
动物模型对于研究结核分枝杆菌感染的发病机制以及测试结核病疫苗和药物治疗方案的疗效具有不可估量的价值。在已应用的动物模型中，非人灵长类动物，尤其是猕猴，与人类在解剖学和生理学上具有最大的相似性。因此，猕猴模型已被用于研究结核病发病机制以及药物和疫苗的临床前测试。本综述重点关注已发表的主要研究，这些研究阐述了恒河猴和食蟹猴如何丰富并可能继续推动全球结核病研究领域的发展。
