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实施全面足部护理计划后,在多学科糖尿病足治疗单元对复发性溃疡进行的分析。

Analysis of recurrent ulcerations at a multidisciplinary diabetic Foot unit after implementation of a comprehensive Foot care program.

作者信息

Jiménez Sara, Rubio José Antonio, Álvarez Julia, Lázaro-Martínez José Luis

机构信息

Unidad de Pie Diabético, Hospital Universitario Príncipe de Asturias , Alcalá de Henares, Madrid, España; Departamento de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.

Unidad de Pie Diabético, Hospital Universitario Príncipe de Asturias , Alcalá de Henares, Madrid, España; Departamento de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España; Departamento de Ciencias Biomédicas, Universidad de Alcalá, Alcalá de Henares, Madrid, España.

出版信息

Endocrinol Diabetes Nutr (Engl Ed). 2018 Oct;65(8):438.e1-438.e10. doi: 10.1016/j.endinu.2018.03.012. Epub 2018 Jun 15.

Abstract

BACKGROUND AND OBJECTIVE

The aim of this study was to assess the risk factors associated to recurrent diabetic foot ulcers after implementing a new preventive comprehensive foot care (CFC) program carried out by a podiatrist and an endocrinologist at a multidisciplinary diabetic foot unit (MDFU) and its potential impact in decreasing recurrent ulcers.

MATERIAL AND METHODS

A retrospective cohort study including consecutive patients who attended the MDFU for the first time from 2008 to 2014 complaining of a diabetic foot ulcer that finally healed. Patients were monitored until ulcer recurred or up to June 30, 2016. Maximum follow-up time was 8.1 years. Cumulative incidence of recurrent ulcers was analyzed during two periods: 2008-2010 (before CFC was implemented) and 2011-2014 (after implementation of CFC).

RESULTS

A total of 280 subjects with a median age of 69.5 years (Q25:60,2-Q75:78) were included. Of these, 64.6% were males and 92.1% had type 2 diabetes mellitus. One hundred and twenty-six (45%) suffered recurrent ulcers. Median time to recurrent ulceration was 0.97 (Q25:0.44-Q75:1.74) years. Multivariate analysis showed sensory neuropathy (HR [95% CI] 1.58 [0.99-2.54], P=.050); minor amputation (HR [95% CI] 1.66 [0.12-2, 46], P=.011); and 2011-2014 period versus 2008-10 period (HR [95% CI] 0.60 [0.42-0.87], P=.007) to be factors independently associated to recurrent ulcers.

CONCLUSIONS

Sensory neuropathy, minor amputation, and implementation of the CFC program were predictors of reulceration. Implementation of the CFC program was associated to a 40% reduction in reulceration. Prevention of recurrent ulcers is feasible and should be a priority in a MDFU.

摘要

背景与目的

本研究旨在评估在一个多学科糖尿病足治疗单元(MDFU)由一名足病医生和一名内分泌学家实施一项新的预防性综合足部护理(CFC)计划后,与糖尿病足溃疡复发相关的风险因素及其对减少溃疡复发的潜在影响。

材料与方法

一项回顾性队列研究,纳入2008年至2014年首次到MDFU就诊、主诉糖尿病足溃疡且最终愈合的连续患者。对患者进行监测,直至溃疡复发或至2016年6月30日。最大随访时间为8.1年。分析两个时期溃疡复发的累积发生率:2008 - 2010年(CFC实施前)和2011 - 2014年(CFC实施后)。

结果

共纳入280名受试者,中位年龄为69.5岁(四分位间距:Q25:60.2 - Q75:78)。其中,64.6%为男性,92.1%患有2型糖尿病。126例(45%)发生溃疡复发。溃疡复发的中位时间为0.97年(四分位间距:Q25:0.44 - Q75:1.74)。多因素分析显示感觉神经病变(HR [95%CI] 1.58 [0.99 - 2.54],P = 0.050);小截肢(HR [95%CI] 1.66 [0.12 - 2.46],P = 0.011);以及2011 - 2014年与2008 - 2010年相比(HR [95%CI] 0.60 [0.42 - 0.87],P = 0.007)是与溃疡复发独立相关的因素。

结论

感觉神经病变、小截肢和CFC计划的实施是溃疡复发的预测因素。CFC计划的实施与溃疡复发减少40%相关。预防溃疡复发是可行的,应成为MDFU的优先事项。

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