Steno Diabetes Centre Copenhagen, Gentofte, Denmark.
Diabet Med. 2019 Nov;36(11):1417-1423. doi: 10.1111/dme.13964. Epub 2019 May 3.
To estimate progression rates, evaluate risk factors for progression, and study rate ratios for progression among people with a healed diabetic foot ulcer according to whether the healed ulcer was neuropathic, neuro-ischaemic or critically ischaemic.
We conducted a retrospective cohort study in all individuals with a healed diabetic foot ulcer treated at the Steno Diabetes Centre Copenhagen foot clinic in the period 2010 to 2016. The outcome of interest was recurrent/other new diabetic foot ulcers.
A total of 780 people had a healed diabetic foot ulcer in the study period (2010-2016). The participants were followed for 1249 person-years [median (Q1-Q3) 1.04 (0.38-2.46) person-years] in total. One-third (33.1%) developed a recurrent/other new diabetic foot ulcer per year. Male gender, people with Type 2 diabetes and smokers had a statistically significantly higher risk of progression to a recurrent/other new diabetic foot ulcer compared to participants without these risk factors. Participants with neuro-ischaemic or critically ischaemic diabetic foot ulcers had statistically significantly higher progression rates than participants with neuropathic diabetic foot ulcers.
Focus should be on preventing future recurrent/other new diabetic foot ulcers especially in people with ischaemia.
根据愈合的糖尿病足溃疡是神经病变性、神经缺血性还是严重缺血性，估计愈合溃疡患者的进展率、评估进展的危险因素，并研究进展的比率。
我们对 2010 年至 2016 年期间在哥本哈根 Steno 糖尿病中心足部诊所接受治疗的所有愈合的糖尿病足溃疡患者进行了回顾性队列研究。研究的结局是复发性/其他新发的糖尿病足溃疡。
在研究期间（2010-2016 年），共有 780 人患有愈合的糖尿病足溃疡。参与者共随访了 1249 人年[中位数（Q1-Q3）1.04（0.38-2.46）人年]。每年有三分之一（33.1%）的人出现复发性/其他新发的糖尿病足溃疡。与无这些危险因素的参与者相比，男性、2 型糖尿病患者和吸烟者发生复发性/其他新发糖尿病足溃疡的风险具有统计学意义。神经缺血性或严重缺血性糖尿病足溃疡患者的进展率明显高于神经病变性糖尿病足溃疡患者。
应特别关注预防未来复发性/其他新发的糖尿病足溃疡，尤其是在有缺血的人群中。
