先天营养免疫。
Innate Nutritional Immunity.
机构信息
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109;
Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109; and.
出版信息
J Immunol. 2018 Jul 1;201(1):11-18. doi: 10.4049/jimmunol.1800325.
Abstract
Iron (Fe) is an essential micronutrient for both microbes and their hosts. The biologic importance of Fe derives from its inherent ability to act as a universal redox catalyst, co-opted in a variety of biochemical processes critical to maintain life. Animals evolved several mechanisms to retain and limit Fe availability to pathogenic microbes, a resistance mechanism termed "nutritional immunity." Likewise, pathogenic microbes coevolved to deploy diverse and efficient mechanisms to acquire Fe from their hosts and in doing so overcome nutritional immunity. In this review, we discuss how the innate immune system regulates Fe metabolism to withhold Fe from pathogenic microbes and how strategies used by pathogens to acquire Fe circumvent these resistance mechanisms.
摘要
铁（Fe）是微生物及其宿主都必需的一种微量元素。Fe 的生物学重要性源于其作为一种普遍的氧化还原催化剂的固有能力，这种能力被广泛应用于各种对维持生命至关重要的生化过程中。动物进化出了几种机制来保留和限制 Fe 对病原微生物的可利用性，这种抵抗机制被称为“营养免疫”。同样，病原微生物也协同进化出了多种有效的机制，从宿主中获取 Fe，并借此克服营养免疫。在这篇综述中，我们讨论了先天免疫系统如何调节 Fe 代谢以阻止 Fe 进入病原微生物，以及病原体获取 Fe 的策略如何绕过这些抵抗机制。
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