耐莫西沙星的鸟分枝杆菌复合群和脓肿分枝杆菌复合群临床分离株中 和 的突变。
Mutations in and in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates.
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
出版信息
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00527-18. Print 2018 Sep.
Abstract
Data on the frequency of and mutations in fluoroquinolone-resistant isolates of the complex (MAC) and the complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in or in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than and mutations contribute to moxifloxacin resistance in these organisms.
摘要
氟喹诺酮类耐药的 复合群（MAC）和 复合群（MABC）中 和 突变的频率数据有限。在我们的分析中，我们在 105 株 MAC 或 MABC 临床分离株中，包括 72 株莫西沙星耐药分离株，均未发现 或 中与耐药相关的突变。我们的研究结果表明，这些菌中莫西沙星耐药的机制除了 和 突变以外，还有其他机制。
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