• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mutations in and in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates.耐莫西沙星的鸟分枝杆菌复合群和脓肿分枝杆菌复合群临床分离株中 和 的突变。
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00527-18. Print 2018 Sep.
2
Moxifloxacin resistance and genotyping of Mycobacterium avium and Mycobacterium intracellulare isolates in Japan.日本鸟分枝杆菌和胞内分枝杆菌分离株的莫西沙星耐药性和基因分型。
J Infect Chemother. 2019 Dec;25(12):995-1000. doi: 10.1016/j.jiac.2019.05.028. Epub 2019 Jun 22.
3
GenoType NTM-DR Performance Evaluation for Identification of Mycobacterium avium Complex and Mycobacterium abscessus and Determination of Clarithromycin and Amikacin Resistance.GenoType NTM-DR 检测试剂盒鉴定鸟分枝杆菌复合群和脓肿分枝杆菌及检测克拉霉素和阿米卡星耐药性的性能评估。
J Clin Microbiol. 2019 Jul 26;57(8). doi: 10.1128/JCM.00516-19. Print 2019 Aug.
4
Genetic mutations in linezolid-resistant Mycobacterium avium complex and Mycobacterium abscessus clinical isolates.耐利奈唑胺鸟分枝杆菌复合群及脓肿分枝杆菌临床分离株中的基因突变
Diagn Microbiol Infect Dis. 2019 May;94(1):38-40. doi: 10.1016/j.diagmicrobio.2018.10.022. Epub 2018 Nov 30.
5
Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.临床结核分枝杆菌分离株中与氟喹诺酮耐药相关的gyrA和gyrB基因突变的频率及地理分布：一项系统评价
PLoS One. 2015 Mar 27;10(3):e0120470. doi: 10.1371/journal.pone.0120470. eCollection 2015.
6
Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium.鉴定 DNA 拓扑异构酶活力和阐明 GyrA 氨基酸取代对禽分枝杆菌氟喹诺酮类耐药性的影响。
Microbiol Spectr. 2023 Jun 15;11(3):e0508822. doi: 10.1128/spectrum.05088-22. Epub 2023 Apr 17.
7
[Detection of mutations in the gyrA and gyrB genes associated with fluoroquinolone-resistance among clinical isolates of Mycobacterium abscessus in China].[中国脓肿分枝杆菌临床分离株中与氟喹诺酮耐药相关的gyrA和gyrB基因突变检测]
Zhonghua Jie He He Hu Xi Za Zhi. 2015 Jul;38(7):507-10.
8
Association between 16S rRNA gene mutations and susceptibility to amikacin in Mycobacterium avium Complex and Mycobacterium abscessus clinical isolates.16S rRNA 基因突变与鸟分枝杆菌复合体和脓肿分枝杆菌临床分离株对阿米卡星敏感性的关系。
Sci Rep. 2021 Mar 17;11(1):6108. doi: 10.1038/s41598-021-85721-5.
9
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.结核分枝杆菌喹诺酮耐药和超敏临床分离株中的新型gyrase突变：突变酶的功能分析
Antimicrob Agents Chemother. 2006 Jan;50(1):104-12. doi: 10.1128/AAC.50.1.104-112.2006.
10
Analysis of mutations in the gyrA and gyrB genes and their association with the resistance of Mycobacterium tuberculosis to levofloxacin, moxifloxacin and gatifloxacin.分析 gyrA 和 gyrB 基因突变与结核分枝杆菌对左氧氟沙星、莫西沙星和加替沙星耐药性的关系。
J Med Microbiol. 2013 Jan;62(Pt 1):108-113. doi: 10.1099/jmm.0.046821-0. Epub 2012 Sep 27.

引用本文的文献

1
Distinct impact of letermovir discontinuation on tacrolimus pharmacokinetics based on concomitant azole antifungal agent.基于同时使用的唑类抗真菌药物，来特莫韦停药对他克莫司药代动力学的不同影响。
Int J Hematol. 2025 Aug;122(2):199-205. doi: 10.1007/s12185-025-04017-w. Epub 2025 Jun 16.
2
Whole-genome phylogenetic analysis of complex from clinical respiratory samples.对临床呼吸道样本中的复合物进行全基因组系统发育分析。
Microbiol Spectr. 2025 Feb 4;13(2):e0160024. doi: 10.1128/spectrum.01600-24. Epub 2025 Jan 10.
3
Durlobactam to boost the clinical utility of standard of care β-lactams against lung disease.杜洛巴坦可提高标准护理β-内酰胺类药物对肺部疾病的临床效用。
Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0104624. doi: 10.1128/aac.01046-24. Epub 2024 Nov 20.
4
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of .由……的抗σ因子RshA功能丧失突变赋予的多药耐受性 。 你提供的原文似乎不完整，句末“of.”后面应该还有具体内容。
Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0105124. doi: 10.1128/aac.01051-24. Epub 2024 Oct 29.
5
Phenotypic drug-susceptibility profiles and genetic analysis based on whole-genome sequencing of Mycobacterium avium complex isolates in Thailand.基于全基因组测序的泰国鸟分枝杆菌复合体分离株表型药物敏感性谱和遗传分析。
PLoS One. 2023 Nov 22;18(11):e0294677. doi: 10.1371/journal.pone.0294677. eCollection 2023.
6
Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium.鉴定 DNA 拓扑异构酶活力和阐明 GyrA 氨基酸取代对禽分枝杆菌氟喹诺酮类耐药性的影响。
Microbiol Spectr. 2023 Jun 15;11(3):e0508822. doi: 10.1128/spectrum.05088-22. Epub 2023 Apr 17.
7
Variability of Complex Isolates Drug Susceptibility Testing by Broth Microdilution.采用肉汤微量稀释法对复杂分离株进行药敏试验的变异性
Antibiotics (Basel). 2022 Dec 4;11(12):1756. doi: 10.3390/antibiotics11121756.
8
High diversity of clinical in China revealed by whole genome sequencing.中国全基因组测序揭示临床的高度多样性。
Front Public Health. 2022 Nov 17;10:989587. doi: 10.3389/fpubh.2022.989587. eCollection 2022.
9
Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus.非规范错配修复蛋白 NucS 调节脓肿分枝杆菌抗生素耐药性的出现。
Microbiol Spectr. 2022 Dec 21;10(6):e0222822. doi: 10.1128/spectrum.02228-22. Epub 2022 Oct 11.
10
Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus.三环吡咯嘧啶类拓扑异构酶 B 抑制剂对脓肿分枝杆菌的活性。
Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0066922. doi: 10.1128/aac.00669-22. Epub 2022 Aug 25.

本文引用的文献

1
Single-nucleotide polymorphisms related to fluoroquinolone and aminoglycoside resistance in isolates.分离株中与氟喹诺酮和氨基糖苷类耐药性相关的单核苷酸多态性
Infect Drug Resist. 2018 Apr 9;11:515-521. doi: 10.2147/IDR.S160899. eCollection 2018.
2
Drug Susceptibility Profiling and Genetic Determinants of Drug Resistance in Mycobacterium kansasii.堪萨斯分枝杆菌的药物敏感性分析及耐药基因的遗传决定因素。
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.01788-17. Print 2018 Apr.
3
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.全基因组分析多药和广泛耐药结核分枝杆菌。
Nat Genet. 2018 Feb;50(2):307-316. doi: 10.1038/s41588-017-0029-0. Epub 2018 Jan 22.
4
A standardised method for interpreting the association between mutations and phenotypic drug resistance in .一种标准化方法，用于解释 突变与表型药物耐药性之间的关联。
Eur Respir J. 2017 Dec 28;50(6). doi: 10.1183/13993003.01354-2017. Print 2017 Dec.
5
Differences in drug susceptibility pattern between Mycobacterium avium and Mycobacterium intracellulare isolated in respiratory specimens.呼吸道标本中分离出的鸟分枝杆菌和胞内分枝杆菌之间药物敏感性模式的差异。
J Infect Chemother. 2018 Apr;24(4):315-318. doi: 10.1016/j.jiac.2017.10.022. Epub 2017 Dec 7.
6
British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD).英国胸科学会非结核分枝杆菌肺病（NTM-PD）管理指南。
Thorax. 2017 Nov;72(Suppl 2):ii1-ii64. doi: 10.1136/thoraxjnl-2017-210927.
7
Meta-analyses and the evidence base for microbial outcomes in the treatment of pulmonary Mycobacterium avium-intracellulare complex disease.鸟分枝杆菌胞内复合群肺病治疗中微生物学结局的Meta分析及证据基础
J Antimicrob Chemother. 2017 Sep 1;72(suppl_2):i3-i19. doi: 10.1093/jac/dkx311.
8
Systematic Review and Meta-analyses of the Effect of Chemotherapy on Pulmonary Mycobacterium abscessus Outcomes and Disease Recurrence.系统评价和荟萃分析化疗对肺部脓肿分枝杆菌结局和疾病复发的影响。
Antimicrob Agents Chemother. 2017 Oct 24;61(11). doi: 10.1128/AAC.01206-17. Print 2017 Nov.
9
Treatment Outcomes of Mycobacterium avium Complex Lung Disease: A Systematic Review and Meta-analysis.鸟分枝杆菌复合体肺病的治疗结局：系统评价和荟萃分析。
Clin Infect Dis. 2017 Oct 1;65(7):1077-1084. doi: 10.1093/cid/cix517.
10
Microbiological and Clinical Outcomes of Treating Non-Mycobacterium Avium Complex Nontuberculous Mycobacterial Pulmonary Disease: A Systematic Review and Meta-Analysis.治疗非结核分枝杆菌肺病的微生物学和临床结局：系统评价和荟萃分析。
Chest. 2017 Jul;152(1):120-142. doi: 10.1016/j.chest.2017.04.166. Epub 2017 Apr 28.

耐莫西沙星的鸟分枝杆菌复合群和脓肿分枝杆菌复合群临床分离株中 和 的突变。

Mutations in and in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates.

机构信息

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

出版信息

Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00527-18. Print 2018 Sep.

DOI:10.1128/AAC.00527-18
PMID:29914959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6125518/
Abstract

Data on the frequency of and mutations in fluoroquinolone-resistant isolates of the complex (MAC) and the complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in or in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than and mutations contribute to moxifloxacin resistance in these organisms.

摘要

氟喹诺酮类耐药的 复合群（MAC）和 复合群（MABC）中 和 突变的频率数据有限。在我们的分析中，我们在 105 株 MAC 或 MABC 临床分离株中，包括 72 株莫西沙星耐药分离株，均未发现 或 中与耐药相关的突变。我们的研究结果表明，这些菌中莫西沙星耐药的机制除了 和 突变以外，还有其他机制。