头孢他洛滨-他唑巴坦对不同β-内酰胺类耐药表型阴沟肠杆菌复合体临床分离株的活性。
Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different β-Lactam Resistance Phenotypes.
机构信息
CHU Clermont-Ferrand, Laboratoire de Bactériologie et CNR de la Résistance aux Antibiotiques, Clermont-Ferrand, France.
UMR INSERM 1071 USC INRA2018, Université Clermont Auvergne, Clermont-Ferrand, France.
出版信息
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00675-18. Print 2018 Sep.
Abstract
The study evaluated the activity of ceftolozane-tazobactam (C/T) against 94 unique clinical isolates of complex (ECC). No difference was observed according to the ECC cluster. The activity greatly varied depending on the β-lactamase-producing profile: 100%, 67%, and 19% of wild-type, extended-spectrum β-lactamase (ESBL)-producing, and AmpC-overproducing strains, respectively, were susceptible to C/T. The use of C/T could be of interest for the treatment of some infections caused by ESBL-producing AmpC-nonoverexpressing ECC isolates.
摘要
本研究评估了头孢洛扎他唑巴坦（C/T）对 94 株独特的复杂性（ECC）临床分离株的活性。根据 ECC 聚类，未观察到差异。根据产β-内酰胺酶的表型，其活性有很大差异：野生型、产超广谱β-内酰胺酶（ESBL）和产 AmpC 酶的菌株，对 C/T 的敏感性分别为 100%、67%和 19%。C/T 的使用可能对治疗某些由产 ESBL 但不表达 AmpC 的 ECC 分离株引起的感染有意义。
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