Neurology Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Mental Health Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Nat Med. 2018 Aug;24(8):1257-1267. doi: 10.1038/s41591-018-0058-y. Epub 2018 Jun 18.
Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for the recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation.
最近的研究强调了在熟练的上肢任务中，健康的初级运动皮层中短暂的低频振荡（LFO；<4 Hz）活动的重要性。这些短暂的振荡活动可能为运动动作建立时间或顺序。在这里，我们表明 LFO 可以跟踪中风后的运动恢复，并且可以作为神经调节的生理靶标。在啮齿动物中，我们发现，在局部场电位和相关的尖峰活动中测量的与伸展相关的 LFO 在中风后减少，并且自发恢复与它们在病变周围皮层中的恢复密切相关。与两个表现出强大 LFO 的非中风受试者相比，患有中风后慢性残疾的人类受试者的感觉运动 LFO 也减少了。与 LFO 预计出现时间同步的电刺激的治疗性传递被发现可显著改善中风动物的熟练伸展。总之，我们的研究结果表明，皮层振荡动力学的恢复或调节对于上肢功能的恢复很重要，并且它们可能成为临床神经调节的新目标。
