Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada.
Horm Cancer. 2018 Aug;9(4):288-294. doi: 10.1007/s12672-018-0336-7. Epub 2018 Jun 18.
Lung cancer is the most common cause of cancer-related deaths worldwide with non-small cell lung cancer (NSCLC) making up most of these cases. Males have poorer overall survival compared to women following a lung cancer diagnosis. Many studies have focused on the effects of estrogen to explain higher survival rates among women, but few have looked at the effects of androgens. We describe the expression of the androgen receptor (AR) and Ki67 in lung cancer specimens in the Manitoba Tumor Bank (MTB) and correlate these factors with patient outcome. Using the MTB, we performed immunohistochemistry on lung cancer tissue to determine expression of the AR and Ki67. These were then correlated with patient outcome. Of the 136 cases, 55% were female and 55% were adenocarcinoma. AR expression was not independently associated with outcome. Ki67 was associated with a significantly higher hazard ratio for death and recurrence (HR 2.19, 95% CI 1.30-3.70; HR 1.92, 95% CI 1.07-3.46, respectively). AR expression modified the effect of Ki67 on outcome, such that when both were expressed, there was no association with recurrence or survival (HR 2.39, 95% CI 1.31-4.36 for AR- Ki67+ vs HR 1.54, 95% CI 0.44-5.37 for AR+ Ki67+). Ki67 was associated with poorer outcomes alone. AR status alone was not associated with outcome. Although the mechanism remains unclear, AR status seems to negate the association of a high Ki67 and poor outcome.
肺癌是全球癌症相关死亡的最常见原因，其中非小细胞肺癌（NSCLC）占了大多数。男性在肺癌确诊后整体生存率较女性差。许多研究都集中在雌激素对解释女性生存率较高的影响，但很少有研究关注雄激素的影响。我们描述了曼尼托巴肿瘤库（MTB）中肺癌标本中雄激素受体（AR）和 Ki67 的表达，并将这些因素与患者的预后相关联。使用 MTB，我们对肺癌组织进行了免疫组织化学检测，以确定 AR 和 Ki67 的表达。然后将这些因素与患者的预后相关联。在 136 例病例中，55%为女性，55%为腺癌。AR 表达与预后无独立相关性。Ki67 与死亡和复发的风险比显著相关（HR 2.19，95%CI 1.30-3.70；HR 1.92，95%CI 1.07-3.46）。AR 表达修饰了 Ki67 对预后的影响，因此当两者都表达时，与复发或生存无关（AR-Ki67+的 HR 为 2.39，95%CI 为 1.31-4.36，而 AR+Ki67+的 HR 为 1.54，95%CI 为 0.44-5.37）。只有 Ki67 与较差的结果相关。AR 状态本身与预后无关。尽管其机制尚不清楚，但 AR 状态似乎否定了高 Ki67 与不良预后的关联。
