Han Bo, Lin Shan, Yu Li-Juan, Wang Rui-Zhi, Wang Yan-Ying
The Second Ward of Oncology Department, The First Hospital of Harbin Medical University, The Tumor Hospital of Harbin Medical University, Harbin, China.
Nucl Med Commun. 2009 Nov;30(11):831-7. doi: 10.1097/MNM.0b013e32832dcfc4.
This work investigates the correlation between positron emission tomography (PET) images and the expressions of survivin, Ki67, and CD34, as well as the clinicopathological characteristics of non-small-cell lung cancer (NSCLC).
Thirty-three NSCLC cases were scanned with ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG), PET before surgery. Tumor resections were used to evaluate the expressions of survivin, Ki67, and CD34 by immunohistochemical assay. Maximum standardized uptake value (SUVmax), immunohistochemical results, as well as clinicopathological characteristics in NSCLC were compared and analyzed.
The average SUVmax for the 33 NSCLC was 10.5 ± 5.4. The expressions of survivin and Ki67 were 84.8% (28 of 33) and 72.7% (24 of 33), respectively. The median count of microvasculature vessel density labeled by CD34 was 24.5 ± 6.7. In the entire group, SUVmax was significantly correlated to Ki67, histological type, as well as clinical type (P = 0.010, 0.048, 0.029, respectively). It revealed a median survival of 33 ± 0.6 months for SUVmax below 11 versus a median survival of 27 ± 1.3 months for SUVmax values above 11 (P = 0.013). There were no significant correlations between SUVmax and expressions of survivin and CD34, and no correlations involving age, sex, differentiation, tumor node metastasis stage, and lymph node metastasis.
SUV-indexed FDG metabolic activity correlated significantly with proliferative activity (Ki67 expression) as well as the histological and clinical tumor type. These biological predictive markers combined with ¹⁸F-FDG PET might provide more useful information on the diagnosis and prognosis of patients with NSCLC. These conclusions require confirmation with further studies.
本研究旨在探讨正电子发射断层扫描（PET）图像与生存素、Ki67和CD34表达之间的相关性，以及非小细胞肺癌（NSCLC）的临床病理特征。
33例NSCLC患者在手术前接受¹⁸F-氟脱氧葡萄糖（¹⁸F-FDG）PET扫描。通过免疫组织化学分析，利用肿瘤切除术评估生存素、Ki67和CD34的表达。比较并分析NSCLC的最大标准化摄取值（SUVmax）、免疫组织化学结果以及临床病理特征。
33例NSCLC的平均SUVmax为10.5±5.4。生存素和Ki67的表达率分别为84.8%（33例中的28例）和72.7%（33例中的24例）。CD34标记的微血管密度中位数为24.5±6.7。在整个研究组中，SUVmax与Ki67、组织学类型以及临床类型显著相关（P值分别为0.010、0.048、0.029）。结果显示，SUVmax低于11时的中位生存期为33±0.6个月，而SUVmax高于11时的中位生存期为27±1.3个月（P = 0.013）。SUVmax与生存素和CD34的表达之间无显著相关性，且与年龄、性别、分化程度、肿瘤淋巴结转移分期以及淋巴结转移均无相关性。
以SUV为指标的FDG代谢活性与增殖活性（Ki67表达）以及肿瘤的组织学和临床类型显著相关。这些生物学预测标志物与¹⁸F-FDG PET相结合，可能为NSCLC患者的诊断和预后提供更有用的信息。这些结论需要进一步研究加以证实。
