School of Life Science, Beijing Institute of Technology, Beijing, China.
Beijing Key Laboratory of Separation and Analysis in Biomedical and Pharmaceuticals, Department of Biomedical Engineering, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China.
Drug Deliv Transl Res. 2018 Oct;8(5):1564-1591. doi: 10.1007/s13346-018-0548-y.
Stem cell research has recently become a hot research topic in biomedical research due to the foreseen unlimited potential of stem cells in tissue engineering and regenerative medicine. For many years, medicine has been facing intense challenges, such as an insufficient number of organ donations that is preventing clinicians to fulfill the increasing needs. To try and overcome this regrettable matter, research has been aiming at developing strategies to facilitate the in vitro culture and study of stem cells as a tool for tissue regeneration. Meanwhile, new developments in the microfluidics technology brought forward emerging cell culture applications that are currently allowing for a better chemical and physical control of cellular microenvironment. This review presents the latest developments in stem cell research that brought new therapies to the clinics and how the convergence of the microfluidics technology with stem cell research can have positive outcomes on the fields of regenerative medicine and high-throughput screening. These advances will bring new translational solutions for drug discovery and will upgrade in vitro cell culture to a new level of accuracy and performance. We hope this review will provide new insights into the understanding of new brain treatments from the perspective of stem cell technology especially regarding regenerative medicine and tissue engineering.
干细胞研究由于其在组织工程和再生医学方面的巨大潜力，最近成为生物医学研究的热门课题。多年来，医学界一直面临着严峻的挑战，例如器官捐献数量不足，这使得临床医生无法满足日益增长的需求。为了试图克服这一遗憾的问题，研究一直致力于开发策略，以促进干细胞的体外培养和研究，作为组织再生的工具。与此同时，微流控技术的新发展提出了新兴的细胞培养应用，目前能够更好地控制细胞的微环境的化学和物理特性。本综述介绍了干细胞研究的最新进展，这些进展为临床带来了新的治疗方法，以及微流控技术与干细胞研究的融合如何对再生医学和高通量筛选领域产生积极的影响。这些进展将为药物发现带来新的转化解决方案，并将体外细胞培养提升到一个新的准确性和性能水平。我们希望本综述将从干细胞技术的角度，特别是关于再生医学和组织工程，为理解新的大脑治疗方法提供新的见解。
