Department of Obstetrics and Gynecology, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Department of Obstetrics and Gynecology, School of Medicine, University of Ioannina, Ioannina, Greece.
Hormones (Athens). 2018 Sep;17(3):293-297. doi: 10.1007/s42000-018-0042-4. Epub 2018 Jun 18.
Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent clinical data regarding the role of CRH in improving clinical pregnancy rates in women with repeated implantation failures following in vitro fertilisation and embryo transfer.
子宫内膜促肾上腺皮质激素释放激素 (CRH) 已被描述为蜕膜化的介质，也是母体-胎儿免疫耐受的贡献者。CRH 表达模式的失调与不良的生殖结局以及慢性子宫内膜源性炎症性疾病（如子宫内膜异位症和子宫腺肌病）有关。本综述总结了关于 CRH 在子宫内膜生理学和病理生理学中作用的证据，并强调了最近关于 CRH 在提高体外受精和胚胎移植后反复着床失败的女性临床妊娠率中的作用的临床数据。
