Rupakheti Binita, Kc Badri, Bista Durga, Kc Sunayana, Pandey Kashi Raj
Department of Pharmacy, School of Science, Kathmandu University, Dhulikhel, Kavrepalanchowk, Nepal.
Department of Languages and Mass Communication, School of Arts, Kathmandu University, Hattiban, Lalitpur, Nepal.
Patient Prefer Adherence. 2024 Oct 1;18:2077-2090. doi: 10.2147/PPA.S476104. eCollection 2024.
Measurement of medication adherence and health-related quality of life is extremely important when planning different health policies. Drug therapy and adherence to medication are critical to prevent complications of hypertension, especially in countries like Nepal, where hypertension is one of the most prevalent diseases. However, this has not been studied in Nepal. This study, hence, aimed to explore medication adherence, factors affecting medication adherence, health-related quality of life, and the correlation between medication adherence and health-related quality of life in hypertensive patients visiting tertiary care health facilities in Lalitpur district of Nepal.
This quantitative cross-sectional study was conducted among 380 hypertensive patients at KIST Medical College and Teaching Hospital, Lalitpur, Nepal. The Nepali version of the European Quality of Life tool EQ-5D-5L and the Hill-Bone Compliance to High Blood Pressure Therapy Scale (HBCTS) were used. Intergroup differences in medication adherence, the EQ-5D index and EQ-VAS scores were assessed for statistical significance using either the Mann-Whitney or Kruskal-Wallis tests for numerical data. Spearman correlation coefficient was used to identify the relationship among medication adherence, EQ-5D-5L index values, and EQ-VAS scores.
The mean treatment score was 22.43 ± 4.12. Age, sex, and occupation were significant factors that affected treatment adherence. The EQ-5D score was 0.72 with age, sex, income, and educational status as significant factors and marital status as an insignificant factor. A slightly negative correlation was found between the total treatment adherence score and the EQ-5D index.
The treatment adherence of patients to antihypertensive therapy was suboptimal, which could affect the outcome of therapy. Better treatment adherence was correlated with a better health-related quality of life. Hence, both health-care providers and patients should make efforts to increase treatment adherence to attain better HRQOL.
在制定不同的卫生政策时，测量药物依从性和健康相关生活质量极为重要。药物治疗和药物依从性对于预防高血压并发症至关重要，尤其是在尼泊尔这样的国家，高血压是最普遍的疾病之一。然而，尼泊尔尚未对此进行研究。因此，本研究旨在探讨尼泊尔拉利特布尔区三级医疗保健机构中高血压患者的药物依从性、影响药物依从性的因素、健康相关生活质量以及药物依从性与健康相关生活质量之间的相关性。
本定量横断面研究在尼泊尔拉利特布尔的KIST医学院和教学医院对380名高血压患者进行。使用了欧洲生活质量工具EQ - 5D - 5L的尼泊尔语版本和希尔 - 博恩高血压治疗依从性量表（HBCTS）。对于数值数据，使用曼 - 惠特尼检验或克鲁斯卡尔 - 沃利斯检验评估药物依从性、EQ - 5D指数和EQ - VAS评分的组间差异是否具有统计学意义。使用斯皮尔曼相关系数来确定药物依从性、EQ - 5D - 5L指数值和EQ - VAS评分之间的关系。
平均治疗评分为22.43±4.12。年龄、性别和职业是影响治疗依从性的重要因素。EQ - 5D评分为0.72，年龄、性别、收入和教育状况是重要因素，婚姻状况是无关因素。在总治疗依从性评分与EQ - 5D指数之间发现了轻微的负相关。
患者对抗高血压治疗的依从性欠佳，这可能会影响治疗效果。更好的治疗依从性与更好的健康相关生活质量相关。因此，医疗保健提供者和患者都应努力提高治疗依从性，以获得更好的健康相关生活质量。
