Adedapo Aduragbenro D A, Akunne Onyinye O, Adedokun Babatunde O
Int J Clin Pharmacol Ther. 2015 Mar;53(3):265-71. doi: 10.5414/CP202257.
Health-related quality of life (HRQOL) in hypertensive patients may be influenced by the presence and the knowledge of disease, beliefs associated with the disease, blood pressure (BP) control, and drug utilization. The impact of hypertension on HRQOL in hypertensive patients compared to the normal population has not been assessed in Nigeria, the most populous country in sub-Saharan Africa. This study compares HRQOL in hypertensive patients and the normal population; the effect of BP control and medication on HRQOL of hypertensive patients is also assessed.
A prospective cross-sectional study of 713 individuals, 606 were hypertensive patients attending the University College Hospital in Oyo State, Nigeria, while 107 were normal persons residing in Ibadan. Data on sociodemographic status, clinical variables, and drug utilization were collected. World health organization-quality of life short version (WHO-QOL-BREF) questionnaires were used to assess HRQOL of participants.
Hypertensive patients had poorer HRQOL compared with normal individuals in the physical health (p<0.05), psychological (p<0.01), and total quality of life domains. Blood pressure control had no effect on HRQOL in domain (p>0.05). Drug use significantly worsened HRQOL of hypertensive patients in the psychological (p˂0.01), social relationship (p<0.01), and the total quality of life domains (p<0.01). Multiple regression analysis showed that while income per month was positively predictive of physical, psychological, and total quality of life domains (r2=1.988, p=0.001; r2=3.710, p<0.001; r2=2.748, p<0.001), symptom count was negatively predictive of the same (r2=-0.746, p=0.005; r2=1.869, p<0.001; and r2=-1.094; p<0.001), respectively. Reduced symptoms and higher income improved quality of life in hypertensive patients.
The presence of hypertension and antihypertensive medication reduced HRQOL of hypertensive patients, although BP control surprisingly did not impact HRQOL. However, lower symptom count and higher income improved quality of life.
高血压患者的健康相关生活质量（HRQOL）可能受到疾病的存在与知晓情况、与疾病相关的信念、血压（BP）控制及药物使用的影响。在撒哈拉以南非洲人口最多的国家尼日利亚，尚未评估高血压患者与正常人群相比，高血压对HRQOL的影响。本研究比较了高血压患者与正常人群的HRQOL；还评估了血压控制和药物治疗对高血压患者HRQOL的影响。
对713名个体进行前瞻性横断面研究，其中606名是在尼日利亚奥约州大学学院医院就诊的高血压患者，107名是居住在伊巴丹的正常人。收集了社会人口学状况、临床变量和药物使用的数据。使用世界卫生组织生活质量简表（WHO-QOL-BREF）问卷评估参与者的HRQOL。
在身体健康（p<0.05）、心理（p<0.01）和总体生活质量领域，高血压患者的HRQOL比正常人差。血压控制在各领域对HRQOL均无影响（p>0.05）。药物使用在心理（p˂0.01）、社会关系（p<0.01）和总体生活质量领域（p<0.01）显著恶化了高血压患者的HRQOL。多元回归分析表明，虽然月收入对身体、心理和总体生活质量领域呈正预测（r2=1.988，p=0.001；r2=3.710，p<0.001；r2=2.748，p<0.001），但症状数量对这些领域呈负预测（r2=-0.746，p=0.005；r2=1.869，p<0.001；r2=-1.094；p<0.001）。症状减少和收入增加改善了高血压患者的生活质量。
高血压的存在和抗高血压药物治疗降低了高血压患者的HRQOL，尽管血压控制出人意料地未对HRQOL产生影响。然而，症状数量减少和收入增加改善了生活质量。
