镍催化的由2,4,6-三氯-1,3,5-三嗪活化的苯酚衍生物的氰化反应

Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine.

作者信息

Wang Liang, Wang Yaoyao, Shen Jun, Chen Qun, He Ming-Yang

机构信息

School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University, Gehu Raod 1, Wujin, Changzhou, 213164, P. R. China.

出版信息

Org Biomol Chem. 2018 Jul 4;16(26):4816-4820. doi: 10.1039/c8ob01034j.

DOI:10.1039/c8ob01034j

PMID:29916504

Abstract

A nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) using aminoacetonitrile as the cyanating agent is described. This catalytic system delivered the desired products in moderate to good yields with good substrate compatibility. The readily available starting materials, cost-effective nickel catalyst and metal-free cyanating agent are the major features of the present method.

摘要

本文描述了一种镍催化的、以氨基乙腈作为氰化剂，对由2,4,6-三氯-1,3,5-三嗪（TCT）活化的苯酚衍生物进行氰化反应的方法。该催化体系能以中等至良好的产率得到所需产物，且底物兼容性良好。本方法的主要特点是起始原料易得、镍催化剂具有成本效益以及使用无金属的氰化剂。