无金属条件下通过硫氰酸钾和硫酸硅作为氰化试剂对羟基、烷氧基和苄氧基芳环的区域选择性单氰化反应。
Metal-Free Regioselective Monocyanation of Hydroxy-, Alkoxy-, and Benzyloxyarenes by Potassium Thiocyanate and Silica Sulfuric Acid as a Cyanating Agent.
机构信息
Chemistry Department, College of Sciences , Shiraz University , Shiraz 71946-84795 , Iran.
Chemistry Department, College of Sciences , University of Sistan and Baluchestan , Zahedan 98167-45845 , Iran.
出版信息
J Org Chem. 2019 Feb 15;84(4):1748-1756. doi: 10.1021/acs.joc.8b02191. Epub 2019 Jan 25.
A novel and efficient metal- and solvent-free regioselective para-C-H cyanation of hydroxy-, alkoxy-, and benzyloxyarene derivatives has been introduced, using nontoxic potassium thiocyanate as a cyanating reagent in the presence of silica sulfuric acid (SSA). The desired products are obtained in good to high yields without any toxic byproducts.
本文介绍了一种新颖高效的金属和溶剂免费的区域选择性对-C-H 氰化羟基、烷氧基和苄氧基芳烃衍生物的方法，使用无毒的硫氰酸钾作为氰化试剂，在硅胶硫酸（SSA）的存在下进行反应。在没有任何有毒副产物的情况下，以良好到高产率得到了所需的产物。
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