Polymer Institute of the Slovak Academy of Sciences , Dubravska cesta 9 , 84541 Bratislava , Slovakia.
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection , "Gheorghe Asachi" Technical University of Iaşi , 700050 Iaşi , Romania.
Biomacromolecules. 2018 Aug 13;19(8):3331-3342. doi: 10.1021/acs.biomac.8b00634. Epub 2018 Jul 3.
The high interest in polymers from natural resources prompted us to investigate the use of enzymatically synthesized polyglobalide (PGL) in the preparation of polymer networks with potential applications as biomaterials for drug delivery devices. Polymer networks were obtained under mild conditions by photoinitiated thiol-ene coupling between PGL and a poly(ethylene glycol- co-thiomalate) (PEG-SH) copolymer obtained by polycondensation. The obtained polymer networks were thoroughly characterized by Raman spectroscopy, scanning electron microscopy, titration of thiol groups and elemental analysis. Our study took into consideration the synthesis parameters for the polymer networks, such as the total polymer concentration and the SH/C=C functionality molar ratio. Swelling in both THF and water was assessed, and the potential of the materials for drug delivery was determined. The scanning electron microscopy images showed that the prepared polymer networks may have different morphologies ranging from homogeneous polymer materials to macroporous structures. Additionally, the prepared materials were found to be suitable from a cytotoxicity point of view, enabling their application as biomaterials for drug delivery devices.
人们对天然资源聚合物的浓厚兴趣促使我们研究了酶合成的聚（全同立构丙烯酰胺）（PGL）在具有作为药物输送装置用生物材料的应用潜力的聚合物网络制备中的应用。在温和条件下，通过 PGL 与通过缩聚获得的聚（乙二醇-co-硫代马来酸酯）（PEG-SH）共聚物之间的光引发的巯基-烯加成反应获得聚合物网络。通过拉曼光谱、扫描电子显微镜、巯基滴定和元素分析对获得的聚合物网络进行了全面的表征。我们的研究考虑了聚合物网络的合成参数，例如聚合物总浓度和 SH/C=C 官能团摩尔比。评估了在 THF 和水中的溶胀，并确定了材料在药物输送中的潜力。扫描电子显微镜图像表明，所制备的聚合物网络可能具有从均相聚合物材料到大孔结构的不同形态。此外，从细胞毒性的角度来看，发现所制备的材料适合用作药物输送装置的生物材料。
