Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea; Institute of Biomedical Industry, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea.
Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea; Institute of Biomedical Industry, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea; Department of Psychiatry, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea.
J Affect Disord. 2018 Oct 1;238:451-457. doi: 10.1016/j.jad.2018.05.023. Epub 2018 May 19.
Although the application of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression has been well investigated, there are few biological predictors of clinical outcomes to rTMS treatment. Previous studies have suggested that the loudness dependence of auditory evoked potentials (LDAEP) can be used as a predictor of response to antidepressant treatment. However, little is known about the association between rTMS and LDAEP. The present study aimed to investigate whether baseline LDAEP is associated with clinical changes to rTMS treatment in patients with major depressive disorder (MDD), and to explore the effect of high-frequency rTMS on LDAEP.
Thirty patients were randomized to receive 15 sessions of active (n = 15) or sham rTMS (n = 15). LDAEP and clinical measures of depression were assessed before and after 10 Hz rTMS treatment for 15 days.
Baseline LDAEP was associated with changes in scores on the Hamilton Rating Scale for Depression. There were no significant effects of rTMS on LDAEP. Patients with high LDAEP exhibited more favorable clinical changes than those with low LDAEP following treatment with rTMS.
The sample was relatively small, and the participants were not divided into responders and non-responders group due to small sample. An influence of medication has not been controlled.
Our findings suggest that high baseline LDAEP may be associated with favorable clinical changes to rTMS treatment in patients with MDD. Further studies are required to replicate and validate the potential use of LDAEP as a predictor of clinical changes to rTMS treatment.
尽管重复经颅磁刺激（rTMS）在治疗抑郁症方面的应用已得到充分研究，但目前用于预测 rTMS 治疗临床疗效的生物学标志物仍较少。既往研究提示，听觉诱发电位响度依赖性（LDAEP）可作为抗抑郁治疗反应的预测指标。然而，rTMS 与 LDAEP 之间的相关性仍知之甚少。本研究旨在探讨躁狂抑郁症（MDD）患者的 LDAEP 基线值是否与 rTMS 治疗的临床变化相关，并探索高频 rTMS 对 LDAEP 的影响。
30 例患者随机分为真刺激（n=15）或假刺激（n=15）rTMS 组。10 Hz rTMS 治疗 15 天后，分别于治疗前后评估 LDAEP 和抑郁的临床量表。
LDAEP 基线值与汉密尔顿抑郁评定量表评分的变化相关。rTMS 对 LDAEP 无显著影响。rTMS 治疗后，LDAEP 值较高的患者比 LDAEP 值较低的患者临床改善更明显。
样本量相对较小，由于样本量较小，未将患者分为反应者和非反应者组。未控制药物的影响。
本研究结果表明，MDD 患者的 LDAEP 基线值较高可能与 rTMS 治疗的临床改善相关。需要进一步研究来复制和验证 LDAEP 作为 rTMS 治疗临床变化预测指标的潜在用途。
