Yoon Sunkyung, Kim Yourim, Lee Seung-Hwan
Department of Psychology, University of South Florida, Tampa, FL, USA.
Clinical Emotion and Cognition Research Laboratory, Goyang, Korea.
Clin Psychopharmacol Neurosci. 2021 May 31;19(2):254-261. doi: 10.9758/cpn.2021.19.2.254.
Loudness of dependence of the auditory evoked potential (LDAEP) is an electroencephalogram-based measure that represents amplitude changes of auditory evoked potentials in primary auditory cortex. Several narrative reviews argued that pre-treatment LDAEP values predict responses to selective serotonin reuptake inhibitors (SSRIs). This study aims to quantify the overall relationship between baseline LDAEP values and treatment response to SSRIs in patients with depression and generalized anxiety disorders, evidenced by clinical symptoms reductions, across multiple studies.
In our meta-analysis, seven articles with a total sample of 241 patients were included.
Our results showed that stronger baseline LDAEP values predicted favorable response to SSRIs for depression and anxiety, with a moderate effect size.
The current results support the idea that LDAEP is a promising biomarker for SSRIs treatment prediction in patients with depression and generalized anxiety disorder.
听觉诱发电位响度依赖性（LDAEP）是一种基于脑电图的测量方法，代表初级听觉皮层中听觉诱发电位的振幅变化。几项叙述性综述认为，治疗前的LDAEP值可预测对选择性5-羟色胺再摄取抑制剂（SSRI）的反应。本研究旨在通过多项研究，量化抑郁症和广泛性焦虑症患者的基线LDAEP值与SSRI治疗反应之间的总体关系，以临床症状减轻为证据。
在我们的荟萃分析中，纳入了7篇文章，总样本量为241例患者。
我们的结果表明，更强的基线LDAEP值预示着对抑郁症和焦虑症患者使用SSRI有良好反应，效应量中等。
目前的结果支持这样一种观点，即LDAEP是预测抑郁症和广泛性焦虑症患者使用SSRI治疗效果的一种有前景的生物标志物。
