University Medical Center Groningen, Department of Health Sciences, Community and Occupational Medicine, University of Groningen, Groningen, The Netherlands.
HumanCapitalCare, Enschede, The Netherlands.
Psychooncology. 2018 Sep;27(9):2229-2236. doi: 10.1002/pon.4800. Epub 2018 Jul 12.
Cancer patients can experience work-specific cognitive symptoms post return to work. The study aims to (1) describe the course of work-specific cognitive symptoms in the first 18 months post return to work and (2) examine the associations of work characteristics, fatigue and depressive symptoms with work-specific cognitive symptoms over time.
This study used data from the 18-month longitudinal "Work Life after Cancer" cohort. The Cognitive Symptom Checklist-Work Dutch Version (CSC-W DV) was used to measure work-specific cognitive symptoms. Linear mixed models were performed to examine the course of work-specific cognitive symptoms during 18-month follow-up; linear regression analyses with generalized estimating equations were used to examine associations over time.
Working cancer patients examined with different cancer types were included (n = 378). Work-specific cognitive symptoms were stable over 18 months. At baseline, cancer patients reported more working memory symptoms (M = 32.0; CI, 30.0-34.0) compared with executive function symptoms (M = 19.3; CI, 17.6-20.9). Cancer patients holding a job with both manual and nonmanual tasks reported less work-specific cognitive symptoms (unstandardized regression coefficient b = -4.80; CI, -7.76 to -1.83) over time, compared with cancer patients with a nonmanual job. Over time, higher depressive symptoms were related to experiencing more overall work-specific cognitive symptoms (b = 1.27; CI, 1.00-1.55) and a higher fatigue score was related to more working memory symptoms (b = 0.13; CI, 0.04-0.23).
Job type should be considered when looking at work-specific cognitive symptoms over time in working cancer patients. To reduce work-specific cognitive symptoms, interventions targeted at fatigue and depressive symptoms might be promising.
癌症患者在重返工作岗位后可能会出现与工作相关的认知症状。本研究旨在：(1)描述重返工作岗位后 18 个月内与工作相关的认知症状的发展过程；(2)随着时间的推移，研究工作特征、疲劳和抑郁症状与工作相关认知症状的关联。
本研究使用了为期 18 个月的纵向“癌症后的工作生活”队列研究的数据。使用认知症状清单-工作荷兰语版（CSC-W DV）来测量与工作相关的认知症状。使用线性混合模型来检测 18 个月随访期间与工作相关的认知症状的发展过程；使用广义估计方程进行线性回归分析，以检测随时间的关联。
研究纳入了患有不同癌症类型的工作癌症患者（n=378）。与工作相关的认知症状在 18 个月内保持稳定。在基线时，癌症患者报告的工作记忆症状（M=32.0；置信区间，30.0-34.0）比执行功能症状（M=19.3；置信区间，17.6-20.9）更多。与从事非体力和非体力工作的癌症患者相比，从事体力和非体力工作的癌症患者报告的与工作相关的认知症状更少（未标准化回归系数 b=-4.80；置信区间，-7.76 至-1.83）。随着时间的推移，较高的抑郁症状与经历更多的整体与工作相关的认知症状相关（b=1.27；置信区间，1.00-1.55），较高的疲劳评分与更多的工作记忆症状相关（b=0.13；置信区间，0.04-0.23）。
在观察工作癌症患者随时间推移的与工作相关的认知症状时，应考虑工作类型。为了减少与工作相关的认知症状，针对疲劳和抑郁症状的干预措施可能是有希望的。
