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催乳素作为免疫细胞调节剂在体幼虫慢性感染中的作用。

Prolactin as immune cell regulator in somatic larvae chronic infection.

机构信息

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México D.F. 04510, México.

Departamento de Genotoxicología, Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de Mèxico.

出版信息

Biosci Rep. 2018 Jul 31;38(4). doi: 10.1042/BSR20180305. Print 2018 Aug 31.

DOI:10.1042/BSR20180305
PMID:29921576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6066655/
Abstract

Toxocariasis is a zoonotic disease produced by ingestion of larval spp. eggs. Prolactin (PRL) has been considered to have an important role in infection. Recent evidence has found that PRL directly can increase parasite growth and differentiation of The present study, evaluated the effect of high PRL levels on the immune system's response and parasites clearance in chronic infection. Our results showed that hyperprolactinemia did not affect the number of larvae recovered from several tissues in rats. Parasite-specific antibody production, showed no difference between the groups. Lung tissue presented eosinophilic granulomas typical of a chronic infection in all the experimental groups. Flow cytometry analysis was made in order to determine changes in the percentage of innate and adaptive immune cell subpopulations in the spleen, peripheric (PLN) and mesenteric (MLN) lymphatic nodes. The results showed a differential effect of PRL and infection on different immune compartments in the percent of total T cells, T helper cells, T cytotoxic cells, B cells, NK cells, and Tγδ cells. To our knowledge, for the first time it is demonstrated that PRL can have an immunomodulatory role during chronic infection in the murine host.

摘要

旋毛虫病是一种由摄入幼虫 spp. 卵引起的人畜共患病。催乳素 (PRL) 被认为在 感染中具有重要作用。最近的证据发现，PRL 可以直接促进寄生虫的生长和分化。本研究评估了高 PRL 水平对慢性感染中免疫系统反应和寄生虫清除的影响。我们的结果表明，高催乳素血症不会影响从大鼠几种组织中回收的幼虫数量。寄生虫特异性抗体产生在各组之间没有差异。肺组织在所有实验组均呈现出慢性感染的嗜酸性粒细胞肉芽肿。进行流式细胞术分析，以确定在脾、外周 (PLN) 和肠系膜 (MLN) 淋巴结中固有和适应性免疫细胞亚群的百分比变化。结果表明，PRL 和感染对总 T 细胞、辅助性 T 细胞、细胞毒性 T 细胞、B 细胞、NK 细胞和 Tγδ 细胞的百分比具有不同的免疫作用。据我们所知，这是首次证明 PRL 在鼠宿主的 慢性感染中具有免疫调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/552730094cb8/bsr-38-bsr20180305-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/07eb74e56cd1/bsr-38-bsr20180305-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/afda2c095cc0/bsr-38-bsr20180305-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/cf18c1472b71/bsr-38-bsr20180305-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/155e759e7011/bsr-38-bsr20180305-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/478d45793578/bsr-38-bsr20180305-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/552730094cb8/bsr-38-bsr20180305-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/07eb74e56cd1/bsr-38-bsr20180305-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/afda2c095cc0/bsr-38-bsr20180305-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/cf18c1472b71/bsr-38-bsr20180305-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/155e759e7011/bsr-38-bsr20180305-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/478d45793578/bsr-38-bsr20180305-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52e9/6066655/552730094cb8/bsr-38-bsr20180305-g6.jpg

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