Kim S J, Gim M S
Department of Psychiatry, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.
East Asian Arch Psychiatry. 2018 Jun;28(2):68-70.
Clozapine is considered to be more effective than other antipsychotic drugs for treating treatmentresistant schizophrenia. However, side effects of clozapine include agranulocytosis and, less commonly, cardiovascular disease, which is occasionally fatal. We describe a 56-year-old woman who developed clozapine-related paroxysmal supraventricular tachycardia during clozapine dose titration and had a recurrence despite being treated with verapamil. For treatment-resistant schizophrenia, a slow titration of the clozapine dose is necessary, and potential cardiac side-effects should be monitored.
氯氮平被认为在治疗难治性精神分裂症方面比其他抗精神病药物更有效。然而，氯氮平的副作用包括粒细胞缺乏症，较少见的还有心血管疾病，后者偶尔会致命。我们描述了一名56岁女性，在氯氮平剂量滴定期间出现了与氯氮平相关的阵发性室上性心动过速，尽管使用维拉帕米治疗仍有复发。对于难治性精神分裂症，必须缓慢滴定氯氮平剂量，并应监测潜在的心脏副作用。
