Different domains of β-glycoprotein I play a role in autoimmune pathogenesis.
作者信息
Sorice Maurizio, Misasi Roberta
机构信息
Department of Experimental Medicine, University of Rome "La Sapienza", viale Regina Elena 324, 00161, Rome, Italy.
出版信息
Cell Mol Immunol. 2020 Nov;17(11):1210-1211. doi: 10.1038/s41423-018-0060-9. Epub 2018 Jun 19.
Abstract
摘要
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Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells.β2-糖蛋白I与阴离子磷脂的结合促进了一个隐蔽表位的加工和呈递，该表位可激活致病性自身反应性T细胞。
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Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.系统性红斑狼疮中的自身抗原聚集在凋亡角质形成细胞表面结构的两个群体中。
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