Peng Jinghua
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China.
Front Pharmacol. 2018 Jun 5;9:455. doi: 10.3389/fphar.2018.00455. eCollection 2018.
Inflammation contributes heavily to the pathogenesis of liver fibrosis, cirrhosis, and even hepatocellular carcinoma. Inflammation is probably a promising target for treatment of liver diseases. The natural products are considered as the potential source of new drug discovery and their pharmacological effects on hepatic inflammation have been widely reported. In this review, the natural products with anti-hepatic inflammatory properties are summarized based on their pharmacological effects and mechanisms, which are related to the suppression on the inflammation mediators including cytokines and chemokines, pattern recognition receptors, the activated transcriptional factors, and the potential regulatory factors. The clinical evidence is also summarized.
炎症在肝纤维化、肝硬化甚至肝细胞癌的发病机制中起着重要作用。炎症可能是治疗肝脏疾病的一个有前景的靶点。天然产物被认为是新药发现的潜在来源，并且它们对肝脏炎症的药理作用已被广泛报道。在本综述中，基于其药理作用和机制，总结了具有抗肝脏炎症特性的天然产物，这些作用和机制与抑制包括细胞因子和趋化因子、模式识别受体、活化转录因子以及潜在调节因子在内的炎症介质有关。同时也总结了临床证据。
