Scheepers Floortje E, de Mul Jos, Boer Frits, Hoogendijk Witte J
Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands.
Faculty of Philosophy, Erasmus University Rotterdam, Rotterdam, Netherlands.
Front Psychiatry. 2018 Jun 5;9:237. doi: 10.3389/fpsyt.2018.00237. eCollection 2018.
From an evolutionary perspective it is remarkable that psychotic disorders, mostly occurring during fertile age and decreasing fecundity, maintain in the human population. To argue the hypothesis that psychotic symptoms may not be viewed as an illness but as an adaptation phenomenon, which can become out of control due to different underlying brain vulnerabilities and external stressors, leading to social exclusion. A literature study and analysis. Until now, biomedical research has not unravelld the definitive etiology of psychotic disorders. Findings are inconsistent and show non-specific brain anomalies and genetic variation with small effect sizes. However, compelling evidence was found for a relation between psychosis and stressful environmental factors, particularly those influencing social interaction. Psychotic symptoms may be explained as a natural defense mechanism or protective response to stressful environments. This is in line with the fact that psychotic symptoms most often develop during adolescence. In this phase of life, leaving the familiar, and safe home environment and building new social networks is one of the main tasks. This could cause symptoms of "hyperconsciousness" and calls on the capacity for social adaptation. Psychotic symptoms may be considered as an evolutionary maintained phenomenon.Research investigating psychotic disorders may benefit from a focus on underlying general brain vulnerabilities or prevention of social exclusion, instead of psychotic symptoms.
从进化的角度来看,精神障碍大多发生在育龄期且会降低生育能力,却仍在人类群体中存在,这一点很值得注意。有一种假说认为,精神症状或许不应被视为一种疾病,而应被看作一种适应现象,由于不同的潜在脑脆弱性和外部压力源,这种适应现象可能会失控,进而导致社会排斥。本文进行了一项文献研究与分析。到目前为止,生物医学研究尚未揭示出精神障碍的确切病因。研究结果并不一致,显示出非特异性的脑异常和效应量较小的基因变异。然而,有确凿证据表明精神错乱与压力性环境因素之间存在关联,尤其是那些影响社会互动的因素。精神症状或许可以解释为对压力环境的一种自然防御机制或保护性反应。这与精神症状最常在青春期出现这一事实相符。在人生的这个阶段,离开熟悉且安全的家庭环境并建立新的社交网络是主要任务之一。这可能会引发“过度意识”症状,并需要社会适应能力。精神症状或许可被视为一种进化中保留下来的现象。研究精神障碍的研究可能会受益于关注潜在的一般脑脆弱性或预防社会排斥,而非精神症状。