Functional Materials and Electrochemistry Laboratory, Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India.
Analyst. 2018 Jul 9;143(14):3451-3457. doi: 10.1039/c8an00642c.
Reduced graphene oxide has been rationally functionalized with histamine for the highly sensitive and selective electrochemical determination of bisphenol A (BPA). Histamine is covalently attached to graphene oxide by amide coupling and the oxygen functionalities of graphene oxide are partially reduced electrochemically. The facilitated electrochemical oxidation of BPA was achieved in neutral pH with functionalized reduced graphene oxide. The pH of the reaction controls the oxidation of BPA. Electrochemical oxidation is not favourable at pH less than the pKa of histamine due to the protonation of the imidazole nitrogen. The electrode is highly sensitive (1727.29 ± 12.48 nA μM-1 cm-2) towards BPA and shows a linear response up to 30 μM of BPA. It could detect as low as 0.03 nM of BPA (S/N = 5). The other coexisting analytes do not interfere with the voltammetric measurement of BPA.
已通过合理的功能化将还原氧化石墨烯与组氨酸结合，用于双酚 A（BPA）的高灵敏度和选择性电化学测定。通过酰胺偶联将组氨酸共价连接到氧化石墨烯上，并且氧化石墨烯的含氧官能团被电化学部分还原。在中性 pH 下，功能化还原氧化石墨烯实现了 BPA 的促进电化学氧化。反应的 pH 控制 BPA 的氧化。由于咪唑氮的质子化，在 pH 小于组氨酸的 pKa 时，电化学氧化是不利的。该电极对 BPA 具有高灵敏度（1727.29 ± 12.48 nA μM-1 cm-2），并在 30 μM 的 BPA 范围内呈现线性响应。它可以检测低至 0.03 nM 的 BPA（S/N = 5）。其他共存分析物不会干扰 BPA 的伏安测量。
