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临床实践中药物遗传学的应用:问题与对策。

Application of pharmacogenetics in clinical practice: problems and solutions.

机构信息

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA.

Memory Disorders Clinic, Riverside Psychiatric Medical Group, Riverside, CA, USA.

出版信息

J Neural Transm (Vienna). 2019 Jan;126(1):109-113. doi: 10.1007/s00702-018-1894-0. Epub 2018 Jun 19.

DOI:10.1007/s00702-018-1894-0
PMID:29922908
Abstract

This paper discusses difficulties of pharmacogenomic data integration into clinical practice. It emphasizes the need for developing simple and easy to use bioinformatics tools to help prescribers to rapidly access and use genetic data in clinical decision-making at the point of encounter.

摘要

本文讨论了将药物基因组学数据整合到临床实践中的困难。它强调了开发简单易用的生物信息学工具的必要性,以帮助临床医生在遇到患者时快速获取和使用遗传数据,从而做出临床决策。

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1
Application of pharmacogenetics in clinical practice: problems and solutions.临床实践中药物遗传学的应用:问题与对策。
J Neural Transm (Vienna). 2019 Jan;126(1):109-113. doi: 10.1007/s00702-018-1894-0. Epub 2018 Jun 19.
2
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs.临床药物遗传学实施联盟指南(CPIC):CYP2C9 与非甾体类抗炎药。
Clin Pharmacol Ther. 2020 Aug;108(2):191-200. doi: 10.1002/cpt.1830. Epub 2020 Apr 28.
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Interpreting and Implementing Clinical Pharmacogenetic Tests: Perspectives From Service Providers.解读与实施临床药物遗传学检测:服务提供者的观点
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[Pharmacogenetics in daily practice].[日常实践中的药物遗传学]
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An analysis of allele, genotype and phenotype frequencies, actionable pharmacogenomic (PGx) variants and phenoconversion in 5408 Australian patients genotyped for CYP2D6, CYP2C19, CYP2C9 and VKORC1 genes.对 5408 名澳大利亚患者 CYP2D6、CYP2C19、CYP2C9 和 VKORC1 基因进行基因分型后的等位基因、基因型和表型频率、可操作的药物基因组学 (PGx) 变异体和表型转化分析。
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Health regulatory communications of well-established safety-related pharmacogenomics associations in six developed countries: an evaluation of alignment.六个发达国家中已确立的与安全性相关的药物基因组学协会的健康监管沟通:一致性评估
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Pharmacogenomics: introduction and use in clinical practice.药物基因组学:概论及临床应用。
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Falls: the adverse drug reaction of the elderly and the impact of pharmacogenetics.跌倒:老年人的药物不良反应及药物遗传学的影响
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引用本文的文献

1
Translating Pharmacogenetics and Pharmacogenomics to the Clinic: Progress in Human and Veterinary Medicine.将药物遗传学和药物基因组学转化应用于临床:人类医学与兽医学的进展
Front Vet Sci. 2019 Feb 11;6:22. doi: 10.3389/fvets.2019.00022. eCollection 2019.

本文引用的文献

1
Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project.在七个欧洲国家实施药物基因组学决策支持:普遍药物基因组学(U-PGx)项目。
J Am Med Inform Assoc. 2018 Jul 1;25(7):893-898. doi: 10.1093/jamia/ocy005.
2
Clinical Pharmacogenetics of Cytochrome P450-Associated Drugs in Children.儿童中细胞色素P450相关药物的临床药物遗传学
J Pers Med. 2017 Nov 2;7(4):14. doi: 10.3390/jpm7040014.
3
A cost-effectiveness analysis of maternal CYP2D6 genetic testing to guide treatment for postpartum pain and avert infant adverse events.
一项关于母体CYP2D6基因检测的成本效益分析,以指导产后疼痛治疗并避免婴儿不良事件。
Pharmacogenomics J. 2018 May 22;18(3):391-397. doi: 10.1038/tpj.2017.33. Epub 2017 Jul 11.
4
Integrating clinical decision support systems for pharmacogenomic testing into clinical routine - a scoping review of designs of user-system interactions in recent system development.将用于药物基因组检测的临床决策支持系统整合到临床常规工作中——对近期系统开发中用户-系统交互设计的范围综述
BMC Med Inform Decis Mak. 2017 Jun 6;17(1):81. doi: 10.1186/s12911-017-0480-y.
5
Cytochrome P450 Structure, Function and Clinical Significance: A Review.细胞色素 P450 结构、功能及临床意义:综述
Curr Drug Targets. 2018;19(1):38-54. doi: 10.2174/1389450118666170125144557.
6
Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.镰状细胞病中安全使用可待因的药物遗传学
Pediatrics. 2016 Jul;138(1). doi: 10.1542/peds.2015-3479.
7
A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions.药物基因检测预防药物不良反应的经济学评价系统综述
Pharmacoeconomics. 2016 Aug;34(8):771-93. doi: 10.1007/s40273-016-0397-9.
8
Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.用于精准医学的前瞻性药物基因组学检测:使用下一代DNA测序和定制的CYP2D6基因分型级联对五个可操作的药物基因组学基因进行综合分析
J Mol Diagn. 2016 May;18(3):438-445. doi: 10.1016/j.jmoldx.2016.01.003. Epub 2016 Mar 3.
9
Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.生理、病理和环境因素对人细胞色素P450 2D6表达和活性的影响及其在精准医学中的意义
Drug Metab Rev. 2015;47(4):470-519. doi: 10.3109/03602532.2015.1101131. Epub 2015 Nov 16.
10
Attitudes of clinicians following large-scale pharmacogenomics implementation.大规模实施药物基因组学后临床医生的态度。
Pharmacogenomics J. 2016 Aug;16(4):393-8. doi: 10.1038/tpj.2015.57. Epub 2015 Aug 11.