用9-[2-羟基-1-(羟甲基)乙氧基甲基]鸟嘌呤治疗巨细胞病毒性视网膜炎。

Treatment of cytomegalovirus retinitis with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine.

作者信息

Felsenstein D, D'Amico D J, Hirsch M S, Neumeyer D A, Cederberg D M, de Miranda P, Schooley R T

出版信息

Ann Intern Med. 1985 Sep;103(3):377-80. doi: 10.7326/0003-4819-103-3-377.

Abstract

Cytomegalovirus infections can cause significant morbidity and mortality in immunosuppressed patients, and present antiviral agents have had little efficacy against these infections. We describe the use of an acyclic nucleoside 9-[2-hydroxy-1-(hydroxymethyl) ethoxy methyl]guanine (BW B759U), in the treatment of two patients with cytomegalovirus retinitis. The efficacy of this agent was evident, with healing of retinal lesions and resolution of viremia and viral shedding. BW B759U appears to be similar pharmacokinetically to intravenous acyclovir in terms of half-life, peak serum levels, and renal excretion.

摘要

巨细胞病毒感染可在免疫抑制患者中导致严重发病和死亡，而现有的抗病毒药物对这些感染几乎没有疗效。我们描述了一种无环核苷9-[2-羟基-1-(羟甲基)乙氧基甲基]鸟嘌呤（BW B759U）在两名巨细胞病毒性视网膜炎患者治疗中的应用。该药物的疗效显著，视网膜病变愈合，病毒血症和病毒排出得到缓解。就半衰期、血清峰值水平和肾排泄而言，BW B759U在药代动力学方面似乎与静脉注射阿昔洛韦相似。