Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California, San Francisco, California.
J Cell Physiol. 2018 Jan;234(1):427-432. doi: 10.1002/jcp.26535. Epub 2018 Jun 19.
p120-catenin (p120) is an important regulator in the function and stability of E-cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability. These data suggest that p120 is required for suppressing epidermal proliferation, promoting epidermal differentiation and maintaining permeability barrier function of the epidermis.
p120 连环蛋白（p120）是 E-钙黏蛋白功能和稳定性的重要调节剂。然而，p120 在表皮中的作用尚不清楚。先前的研究表明，p120 的全局敲除导致表皮增殖增加，但表皮分化和通透性变化很小。在本研究中，我们生成了一个条件性敲除小鼠模型，并检测了表皮增殖、分化和通透性。结果表明，表皮中 p120 的条件性敲除不仅导致表皮增殖增加，还导致表皮分化减少和通透性增加。这些数据表明，p120 是抑制表皮增殖、促进表皮分化和维持表皮通透性屏障功能所必需的。
