p120连环蛋白在生理和疾病中的功能。
Functions of p120-catenin in physiology and diseases.
作者信息
Jin Xin, Lin Ting, Wang Yunjuan, Li Xiaoqian, Yang Yanhong
机构信息
The First Affiliated Hospital (The First School of Clinical Medicine), Guangdong Pharmaceutical University, Guangzhou, China.
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
出版信息
Front Mol Biosci. 2024 Oct 21;11:1486576. doi: 10.3389/fmolb.2024.1486576. eCollection 2024.
p120-catenin (p120) plays a vital role in regulating cell-cell adhesion at adherens junctions, interacting with the juxtamembrane domain (JMD) core region of E-cadherin and regulates the stability of cadherin at the cell surface. Previous studies have shown significant functions of p120 in cell-cell adhesion, tumor progression and inflammation. In this review, we will discuss recent progress of p120 in physiological processes and diseases, and focus on the functions of p120 in the regulation of cancer and inflammation.
p120连环蛋白（p120）在调节黏着连接中的细胞间黏附中起着至关重要的作用，它与E-钙黏蛋白的近膜结构域（JMD）核心区域相互作用，并调节钙黏蛋白在细胞表面的稳定性。先前的研究表明p120在细胞间黏附、肿瘤进展和炎症中具有重要功能。在这篇综述中，我们将讨论p120在生理过程和疾病中的最新进展，并重点关注p120在癌症和炎症调节中的功能。
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