Hoffmann Tamara, Corrêa-Fissmer Mariane, Duarte Camila Soares, Nazário Rayane Felippe, Barranco Ana Beatriz Sanches, Oliveira Karen Waleska Knipoff de
Medical Specialties Outpatient Clinic, Department of Medicine, Universidade do Sul de Santa Catarina, Tubarão, SC, Brazil.
Department of Sensory System, Medicine Course, Universidade do Sul de Santa Catarina, Tubarão, SC, Brazil.
An Bras Dermatol. 2018 Jun;93(3):362-367. doi: 10.1590/abd1806-4841.20186541.
Internal malignancies such as breast cancer, as well as their treatment can often result in skin changes.
To assess the prevalence of dermatological complaints in patients who are undergoing oncological treatment for breast cancer in a hospital in Tubarão, Santa Catarina, Brazil.
Observational, cross-sectional study, from October 2015 to February 2016 in which 152 patients with the diagnosis of breast cancer, undergoing treatment with chemotherapy, radiotherapy, hormone therapy and/or surgery, were interviewed and completed a research protocol developed by the author.
The treatment of breast cancer was associated with dermatological complaints in 94.1% of the interviewed, being with hair loss the most frequent, present in 79.6% of the sample, followed by nail changes (56%). Patients with lighter skin phototypes (I, II and III) had a lower risk (p=0.045) of developing skin changes when compared to darker phototypes. Radiation therapy (p=0.011) and oncological surgery (pFisher=0.004) were statistically significant when related to skin changes.
Inherent to the design of the study, as well as recall bias.
It was found that most patients diagnosed with breast cancer showed dermatologic manifestations during the proposed cancer treatment. Patients undergoing radiotherapy and surgery showed skin changes with greater statistical significance.
乳腺癌等体内恶性肿瘤及其治疗常常会导致皮肤变化。
评估巴西圣卡塔琳娜州图巴朗市一家医院中正在接受乳腺癌肿瘤治疗的患者皮肤问题的发生率。
2015年10月至2016年2月进行的观察性横断面研究,对152例诊断为乳腺癌且正在接受化疗、放疗、激素治疗和/或手术的患者进行访谈,并让他们完成作者制定的研究方案。
94.1%的受访患者的乳腺癌治疗与皮肤问题有关,其中脱发最为常见,占样本的79.6%,其次是指甲变化(56%)。与肤色较深的患者相比,肤色较浅(I、II和III型)的患者发生皮肤变化的风险较低(p=0.045)。放疗(p=0.011)和肿瘤手术(p费舍尔检验=0.004)与皮肤变化相关时具有统计学意义。
研究设计固有的局限性以及回忆偏倚。
发现大多数诊断为乳腺癌的患者在拟定的癌症治疗期间出现了皮肤表现。接受放疗和手术的患者出现皮肤变化的统计学意义更大。