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复发性阿弗他溃疡:病因、治疗及鉴别诊断的流行病学研究

Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis.

作者信息

Queiroz Salomão Israel Monteiro Lourenço, Silva Marcus Vinícius Amarante da, Medeiros Ana Miryam Costa de, Oliveira Patrícia Teixeira de, Gurgel Bruno Cesar de Vasconcelos, Silveira Éricka Janine Dantas da

机构信息

Oral Pathology Post-Graduation Program, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Odontology Department, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

出版信息

An Bras Dermatol. 2018 Jun;93(3):341-346. doi: 10.1590/abd1806-4841.20186228.

DOI:10.1590/abd1806-4841.20186228
PMID:29924245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6001102/
Abstract

BACKGROUND

Recurrent aphthous ulcerations are common benign ulcerated lesions on the mouth, whose etiology is poorly understood, with controversial treatment and difficult to control in clinical practice.

OBJECTIVE

To evaluate the cases of recurrent aphthous ulcerations with a focus on treatment, diagnosis and etiology.

METHODS

This is a retrospective study of the cases of the Oral Diagnosis service of the Rio Grande do Norte Federal University in Natal/RN. Data such as sex, age, race, location, smoking habits, types of treatment, relapsing episodes, laboratory test results and clinical characteristics were collected. The associations between the variables were analyzed using the Pearson Chi-square test (p <0.05).

RESULTS

A total of 4895 patients were seen in the service over a period of 11 years. Of these, 161 (3.3%) had complaints of oral aphthous ulcerations, of which 76 (47.2%) were diagnosed as suffering from recurrent aphthous ulcerations and 68 (42.2%) with clinical information necessary for evaluation. The tongue was the most affected anatomical region, with 27 individuals (39.7%), followed by the buccal mucosa, with 22 cases (32.3%).

STUDY LIMITATIONS

Retrospective study with data from medical records.

CONCLUSION

Dental surgeons, dermatologists and otorhinolaryngologists are the main responsible for the first contact with patients with this disease and should be attentive to the clinical aspects and treat each patient in an individualized way, since the therapy is palliative, its diagnosis is by exclusion and its etiology is unknown.

摘要

背景

复发性阿弗他溃疡是口腔常见的良性溃疡性病变,其病因尚不清楚,治疗存在争议,临床实践中难以控制。

目的

评估复发性阿弗他溃疡病例,重点关注治疗、诊断和病因。

方法

这是一项对北里奥格兰德联邦大学纳塔尔分校口腔诊断科病例的回顾性研究。收集了性别、年龄、种族、溃疡部位、吸烟习惯、治疗类型、复发次数、实验室检查结果和临床特征等数据。使用Pearson卡方检验分析变量之间的关联(p<0.05)。

结果

在11年期间,该科室共诊治了4895例患者。其中,161例(3.3%)有口腔阿弗他溃疡症状,其中76例(47.2%)被诊断为复发性阿弗他溃疡,68例(42.2%)有评估所需的临床信息。舌头是受影响最严重的解剖区域,有27例(39.7%),其次是颊黏膜,有22例(32.3%)。

研究局限性

基于病历数据的回顾性研究。

结论

牙科医生、皮肤科医生和耳鼻喉科医生是首次接触此类疾病患者的主要责任人,应注意临床症状,对每位患者进行个体化治疗,因为该病治疗为姑息性,诊断靠排除法,病因不明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/e7384ebd807a/abd-93-03-0341-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/be51ab3fb38a/abd-93-03-0341-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/ac277f2e9fe1/abd-93-03-0341-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/e7384ebd807a/abd-93-03-0341-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/be51ab3fb38a/abd-93-03-0341-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/ac277f2e9fe1/abd-93-03-0341-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/6001102/e7384ebd807a/abd-93-03-0341-g03.jpg

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