Lavaee Fatemeh, Parhizkar Elahehnaz, Tavakoli Fatemeh, Zarshenas Mohammad M, Asmarian Naeimehossadat
Oral and Maxillofacial Disease Department, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Exp Dent Res. 2024 Aug;10(4):e920. doi: 10.1002/cre2.920.
The purpose of this study was to determine the therapeutic effect of the Punica granatum (PG) flower on recurrent aphthous stomatitis in comparison with corticosteroid therapy.
This cross-over randomized clinical trial was conducted on the patients who had been referred to Shiraz Dental School for their RAS in 2021. All the participants used both P. granatum flower tablets and Triadent a month apart for wash-out time and all compared themselves. In the experimental group, 30 patients received pomegranate flower tablets, three tablets daily, for 6 days. In the control group, oral paste Triadent has been prescribed three times a day for 6 days. The visual analog scale (VAS) and the size of RAS were evaluated on Days 0-6. Data were analyzed by SPSS version 21. The Wilcoxon test was used.
The mean age of participants was 27.8 ± 14.77 years old. In this study, 15 patients (50%) were men and 15 patients (50%) were women. The mean value of VAS after using prescribed treatment in both evaluated groups on all days was significantly different such that the VAS values were lower for PG flower tablets than Triadent (p value < 0.05). The size of oral lesions in participants who used PG flower tablets was significantly less than those who used Triadent on all evaluation days (p value < 0.05) except on Day 1 (p value = 0.29). The descending slope of VAS from Days 1 to 6 for both Triadent and PG flower tablet users was significant and noticeable. (p value < 0.05).
According to the result of this study, both P. granatum flower tablet and Triadent are useful in reducing the size, period of healing, and VAS of patients with RAS, but the PG flower tablet is more effective.
本研究旨在比较石榴（PG）花与皮质类固醇疗法对复发性阿弗他口炎的治疗效果。
本交叉随机临床试验于2021年对转诊至设拉子牙科学院治疗复发性阿弗他口炎的患者进行。所有参与者在一个月的洗脱期内分别使用石榴花片和曲安奈德口腔糊剂，并进行自我对照。实验组30例患者服用石榴花片，每日3片，共6天。对照组患者每日使用3次曲安奈德口腔糊剂，共6天。在第0至6天评估视觉模拟量表（VAS）和复发性阿弗他口炎的大小。数据采用SPSS 21版进行分析，使用Wilcoxon检验。
参与者的平均年龄为27.8±14.77岁。本研究中，15例患者（50%）为男性，15例患者（50%）为女性。在所有评估日，两个评估组在使用规定治疗后的VAS平均值均有显著差异，石榴花片的VAS值低于曲安奈德口腔糊剂（p值<0.05）。除第1天（p值=0.29）外，在所有评估日，使用石榴花片的参与者口腔病变大小显著小于使用曲安奈德口腔糊剂的参与者（p值<0.05）。曲安奈德口腔糊剂和石榴花片使用者从第1天到第6天VAS的下降斜率均显著且明显（p值<0.05）。
根据本研究结果，石榴花片和曲安奈德口腔糊剂均有助于减小复发性阿弗他口炎患者的病变大小、缩短愈合时间并降低VAS，但石榴花片更有效。
