Max Planck Institute for Demographic Research, Rostock, Germany.
Institute for Sociology and Demography, University of Rostock, Germany.
J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):742-747. doi: 10.1093/gerona/gly104.
This study investigates the accuracy of the reporting of medication use by proxy- and self-respondents, and it compares the prognostic value of the number of medications from survey and registry data for predicting mortality across self- and proxy-respondents.
The study is based on the linkage of the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study with the Danish National Prescription Registry. We investigated the concordance between survey and registry data, and the prognostic value of medication use when assessed using survey and registry data, to predict mortality for self- and proxy-respondents at intake surveys.
Among self-respondents, the agreement was moderate (κ = 0.52-0.58) for most therapeutic groups, whereas among proxy-respondents, the agreement was low to moderate (κ = 0.36-0.60). The magnitude of the relative differences was, generally, greater among proxies than among self-respondents. Each additional increase in the total number of medications was associated with 7%-8% mortality increase among self- and 4%-6% mortality increase among proxy-respondents in both the survey and registry data. The predictive value of the total number of medications estimated from either data source was lower among proxies (c-statistic = 0.56-0.58) than among self-respondents (c-statistic = 0.74).
The concordance between survey and registry data regarding medication use and the predictive value of the number of medications for mortality were lower among proxy- than among self-respondents.
本研究调查了代理和自我报告者在报告用药情况方面的准确性，并比较了来自调查和登记数据的用药数量预测自我和代理报告者死亡率的预后价值。
该研究基于丹麦双胞胎纵向研究和丹麦 1905 队列研究与丹麦国家处方登记处的链接。我们调查了调查和登记数据之间的一致性，以及使用调查和登记数据评估时用药情况对预测自我和代理报告者入组调查时死亡率的预后价值。
在自我报告者中，大多数治疗组的一致性为中等（κ=0.52-0.58），而在代理报告者中，一致性为低到中等（κ=0.36-0.60）。相对于自我报告者，代理报告者的相对差异幅度通常更大。在调查和登记数据中，每种药物总剂量的增加与自我报告者死亡率增加 7%-8%和代理报告者死亡率增加 4%-6%相关。无论从哪个数据源估计，药物总剂量的预测值在代理报告者中（c 统计量=0.56-0.58）均低于自我报告者（c 统计量=0.74）。
在用药方面，调查和登记数据之间的一致性以及药物数量对死亡率的预测价值在代理报告者中均低于自我报告者。
