Ferreira J-C-A, Catunda I-S, Vasconcelos B-C-E, da Silva K-A-A, Nogueira E-F-C, Vidal E-E
Department of Oral and MaxilloFacial Surgery, University of Pernambuco, Avenue General Newton Cavalcante, 1650 Camaragibe, PE, Brazil,
Med Oral Patol Oral Cir Bucal. 2018 Jul 1;23(4):e493-e497. doi: 10.4317/medoral.22374.
To evaluate the serum level of the local anesthetic mepivacaine 3% without vasoconstrictor in patients who underwent procedures performed in the anterior and posterior maxilla, through a method of possible extraction to quantify it in human plasma by high performance liquid chromatography (HPLC).
This was a hybrid study consisting of 18 patients (7 females and 11 males) classified as ASA I, adults and with normal body mass index, submitted to procedures in the anterior region (group I) and posterior region of the maxilla (group II). For 40 minutes, five 6 ml blood samples were collected every 10 minutes after infiltrative injection in each region of the maxilla. Serum levels of the drug were obtained through HPLC. Blood pressure (BP) and heart rate (HR) were measured throughout the procedure.
When compared to the general average of the concentrations of each group, significant values (p <0.05) with greater absorption were observed for the anterior region of the maxilla (group I). There was no significant difference when comparing blood pressure (BP) and heart rate (HR) values.
The concentrations found are safe for infiltrative anesthesia in the analyzed patients, there was a higher plasma level of the local anesthetic in the anterior region of the maxilla and there was no change in HR and BP in relation to the anesthetized area.
通过一种可能的提取方法，利用高效液相色谱法（HPLC）在人血浆中对其进行定量，以评估在进行上颌前部和后部手术的患者中不含血管收缩剂的3%甲哌卡因的血清水平。
这是一项混合研究，包括18名患者（7名女性和11名男性），分类为ASA I级，成年且体重指数正常，接受上颌前部区域（I组）和上颌后部区域（II组）的手术。在每个上颌区域浸润注射后，每隔10分钟采集5份6毫升血样，共采集40分钟。通过HPLC获得药物的血清水平。在整个过程中测量血压（BP）和心率（HR）。
与每组浓度的总体平均值相比，上颌前部区域（I组）观察到具有更高吸收的显著值（p <0.05）。比较血压（BP）和心率（HR）值时没有显著差异。
所发现的浓度对所分析患者的浸润麻醉是安全的，上颌前部区域局部麻醉剂的血浆水平较高，并且与麻醉区域相关的HR和BP没有变化。
