Department of Paediatrics, Jos University Teaching Hospital, Jos, Nigeria.
Department of Community Medicine, Jos University Teaching Hospital, Jos, Nigeria.
PLoS One. 2018 Jun 20;13(6):e0196971. doi: 10.1371/journal.pone.0196971. eCollection 2018.
The Outpatient Therapeutic Program (OTP) for treatment brings the management of Severe Acute Malnutrition (SAM) closer to the community. Many lives have been saved through this approach, but little data exists on the outcome of the children after discharge from such programmes. This study was aimed to determine the survival and nutritional status of children at six months after discharge from OTP for SAM.
This was a prospective study of children with SAM admitted into 10 OTPs in two local government areas of Jigawa state from June 2016 to July 2016. Home visits at six months after discharge enabled the collection of data on survival and nutritional status. The primary outcome measures were survival and nutritional status (Mid upper arm circumference and weight-for-height z-score).
Of 494 children with SAM, 410 were discharged and 379 were followed up. Of these, 354, (93.4%) were found alive while 25 (6.6%) died. Among the survivors 333 (94.1%) had MUAC ≥12.5cm and 64 (18.1%) had WHZ<-3. Mortality rates were higher 10 (8.4%) among the 6-11months old. Most deaths 16 (64%) occurred within the first 3months post-discharge. Those who died were significantly more stunted, p = 0.016 and had a smaller head circumference, p = 0.005 on entry to OTP programme. There was improvement from admission to six months follow up in the number of children with complete immunization (27.4% to 35.6%), and a decrease in the number of unimmunized children (34.8% vs 20.6%) at follow-up.
The study demonstrates good post discharge survival rate and improved nutritional status for SAM patients managed in OTPs. There were, however considerable post discharge mortality, especially in the first three months and lower immunization uptake post discharge. A follow-up programme will improve these indices further.
门诊治疗方案(OTP)将严重急性营养不良(SAM)的管理推向社区。通过这种方法挽救了许多生命,但关于此类方案出院后儿童的结局数据很少。本研究旨在确定 SAM 患儿从 OTP 出院后 6 个月的生存率和营养状况。
这是一项针对 2016 年 6 月至 7 月在 Jigawa 州两个地方政府区的 10 个 OTP 收治的 SAM 患儿的前瞻性研究。出院后 6 个月的家庭访视使我们能够收集有关生存和营养状况的数据。主要结局指标为生存率和营养状况(上臂中部周长和身高体重 z 评分)。
在 494 名 SAM 患儿中,有 410 名患儿出院,有 379 名患儿得到了随访。其中,354 名(94.1%)患儿存活,25 名(6.6%)患儿死亡。在幸存者中,333 名(94.1%)患儿的 MUAC≥12.5cm,64 名(18.1%)患儿的 WHZ<-3。6-11 月龄患儿的死亡率较高(10 例,8.4%)。大多数死亡(16 例,64%)发生在出院后 3 个月内。死亡患儿入院时明显更矮(p=0.016),头围更小(p=0.005)。从入院到出院后 6 个月,完全免疫接种的患儿比例从 27.4%增加到 35.6%,未免疫接种的患儿比例从 34.8%下降到 20.6%。
本研究表明,在 OTP 中管理的 SAM 患者出院后的生存率和营养状况良好。然而,出院后死亡率相当高,尤其是在前三个月,出院后的免疫接种率也较低。后续的随访方案将进一步改善这些指标。