d'Almeida M, Sagbo G, Lalya F, Alao M J, d'Almeida C, Agossou J, Koumakpai S, Ayivi B
Service de Pédiatrie et de Génétique Médicale, CNHU, Cotonou, Bénin.
Service de Pédiatrie, Hôpital de la Mère et de l'Enfant, Cotonou, Bénin.
Mali Med. 2013;28(1):25-29.
To describe the profile of HIV-infected children.
This was a cross-sectional, descriptive and analytic study involving 317 infected children, monitored from January 1st, 2002 to July 31st, 2010 at CNHU of Cotonou.
The average age was 89.1 months with a sex ratio of 0.91. Orphans of at least one parent represented 31.3% of cases. Vertical transmission was predominant (86.1%). Only 9.5% of patients benefited from PMTCT. They were all infected with HIV 1. According to the WHO classification, 52% were at stage 3 or 4 and 56% had advanced to severe immunodeficiency. 61% had suffered from opportunistic infections, and 53% had benefited from antiretroviral therapy. Following the study, 54% of participants had continued follow-up visits, 23% lost contact with the CNHU, 18% died and 5% were referred to another site. Factors associated with outcome were antiretroviral therapy (p < 0.0001), clinical (p < 0.0001) and immunological stage (p = 0.0042) on admission.
Our findings suggest strengthening the PMTCT program, screening and early management of an HIV infection.
描述感染艾滋病毒儿童的概况。
这是一项横断面、描述性和分析性研究，涉及317名受感染儿童，于2002年1月1日至2010年7月31日在科托努的CNHU进行监测。
平均年龄为89.1个月，性别比为0.91。至少有一位家长是孤儿的病例占31.3%。垂直传播占主导（86.1%）。只有9.5%的患者受益于预防母婴传播。他们均感染了HIV-1。根据世界卫生组织的分类，52%处于3期或4期，56%已发展为严重免疫缺陷。61%曾患机会性感染，53%曾接受抗逆转录病毒治疗。研究结束后，54%的参与者继续接受随访，23%与CNHU失去联系，18%死亡，5%被转诊至另一机构。与结局相关的因素为入院时的抗逆转录病毒治疗（p<0.0001）、临床（p<0.0001）和免疫分期（p=0.0042）。
我们的研究结果表明应加强预防母婴传播项目、艾滋病毒感染的筛查和早期管理。
