精神分裂症患者循环中血管紧张素转换酶（ACE）水平降低。
Lower circulating levels of angiotensin-converting enzyme (ACE) in patients with schizophrenia.
机构信息
Neuropsychiatry Program & Immuno-Psychiatry Lab, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America.
Neuroscience Program, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil.
出版信息
Schizophr Res. 2018 Dec;202:50-54. doi: 10.1016/j.schres.2018.06.023. Epub 2018 Jun 18.
This study aimed at evaluating changes in the renin-angiotensin system (RAS) in patients with schizophrenia in comparison with controls. Plasma levels of angiotensin-converting enzyme (ACE), ACE2, angiotensin (Ang)-(1-7) and Ang II were assessed in 25 patients with schizophrenia and 20 controls. Patients with schizophrenia presented decreased levels of ACE compared to controls [median (25th-75th percentiles) = 434.79 (341.15-524.02) vs. 508.49 (396.34-608.72); p < 0.05]. No significant differences were found regarding ACE2, Ang-(1-7) and Ang II levels. There were no associations between the measured molecules and clinical parameters. Our results corroborate the hypothesis that the RAS is involved in the pathophysiology of schizophrenia.
本研究旨在评估与对照组相比，精神分裂症患者肾素-血管紧张素系统 (RAS) 的变化。在 25 名精神分裂症患者和 20 名对照者中评估了血管紧张素转换酶 (ACE)、ACE2、血管紧张素 (Ang)-(1-7) 和 Ang II 的血浆水平。与对照组相比，精神分裂症患者的 ACE 水平降低[中位数（25 分位数-75 分位数）=434.79（341.15-524.02）比 508.49（396.34-608.72）；p<0.05]。ACE2、Ang-(1-7) 和 Ang II 水平无显著差异。所测量的分子与临床参数之间没有关联。我们的结果证实了 RAS 参与精神分裂症病理生理学的假说。
Zotero 插件