Sanches Marsal, Colpo Gabriela D, Cuellar Valeria A, Bockmann Taya, Rogith Deevakar, Soares Jair C, Teixeira Antonio L
Department of Psychiatry and Behavioral Sciences, UT Center of Excellence on Mood Disorders, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Front Neurosci. 2021 Feb 11;15:617888. doi: 10.3389/fnins.2021.617888. eCollection 2021.
Dysfunctions in the renin-angiotensin system (RAS) seem to be involved in the pathophysiology of several mental illness, including schizophrenia and mood disorders. We carried out a cross-sectional study assessing the levels of RAS-related molecules among bipolar disorder (BD) patients compared to healthy controls.
our sample consisted of 30 outpatients with BD type 1 (10 males, 20 females, age = 35.53 ± 10.59 years, 14 euthymic, 16 experiencing mood episodes) and 30 healthy controls (10 males, 20 females, age = 34.83 ± 11.49 years). Plasma levels of angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2), angiotensin-II (Ang II), and angiotensin (1-7) [Ang-(1-7)] were determined by ELISA.
BD patients experiencing ongoing mood episodes had significantly lower ACE levels compared to controls (median: 459.00 vs. 514.10, < 0.05). There was no association between the levels of these biomarkers and clinical parameters.
Our findings support the involvement of RAS dysfunction in the pathophysiology of BD. Considering the potential therapeutic implications linked to a better understanding of the role of RAS dysfunction in BD, studies allowing a better characterization of RAS-related molecules level and activity across different mood states are of high interest.
肾素-血管紧张素系统（RAS）功能障碍似乎参与了包括精神分裂症和情绪障碍在内的多种精神疾病的病理生理过程。我们开展了一项横断面研究，评估双相情感障碍（BD）患者与健康对照者中RAS相关分子的水平。
我们的样本包括30例1型双相情感障碍门诊患者（10例男性，20例女性，年龄 = 35.53 ± 10.59岁，14例处于心境正常期，16例处于情绪发作期）和30例健康对照者（10例男性，20例女性，年龄 = 34.83 ± 11.49岁）。采用酶联免疫吸附测定法（ELISA）测定血浆中血管紧张素转换酶（ACE）、血管紧张素转换酶2（ACE2）、血管紧张素II（Ang II）和血管紧张素（1-7）[Ang-(1-7)]的水平。
与对照组相比，处于情绪发作期的双相情感障碍患者的ACE水平显著降低（中位数：459.00对514.10，<0.05）。这些生物标志物的水平与临床参数之间无关联。
我们的研究结果支持RAS功能障碍参与双相情感障碍的病理生理过程。鉴于更好地理解RAS功能障碍在双相情感障碍中的作用可能具有的治疗意义，开展能够更好地表征不同情绪状态下RAS相关分子水平和活性的研究具有很高的价值。
