Saladino Raffaele, Šponer Judit E, Šponer Jiří, Costanzo Giovanna, Pino Samanta, Di Mauro Ernesto
Biological and Ecological Department, University of Tuscia, 01100 Viterbo, Italy.
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61265 Brno, Czech Republic.
Life (Basel). 2018 Jun 20;8(2):24. doi: 10.3390/life8020024.
Molecular Darwinian evolution is an intrinsic property of reacting pools of molecules resulting in the adaptation of the system to changing conditions. It has no a priori aim. From the point of view of the origin of life, Darwinian selection behavior, when spontaneously emerging in the ensembles of molecules composing prebiotic pools, initiates subsequent evolution of increasingly complex and chemical information. On the side, it is a posteriori observed that numerous biological processes are based on prebiotically promptly made compounds, as proposed by the concept of Chemomimesis. Molecular Darwinian evolution and Chemomimesis are principles acting in balanced cooperation in the frame of Systems Chemistry. The one-pot synthesis of nucleosides in radical chemistry conditions is possibly a telling example of the operation of these principles. Other indications of similar cases of molecular evolution can be found among biogenic processes.
分子达尔文进化是反应分子池的一种内在属性，它使系统能够适应不断变化的条件。它没有先验目标。从生命起源的角度来看，当达尔文选择行为在构成前生物池的分子集合中自发出现时，就会引发随后越来越复杂的化学信息的进化。另一方面，从后验的角度观察到，正如化学模拟概念所提出的那样，许多生物过程是基于前生物快速生成的化合物。分子达尔文进化和化学模拟是在系统化学框架内平衡协作发挥作用的原理。在自由基化学条件下核苷的一锅法合成可能是这些原理运作的一个显著例子。在生物发生过程中也能找到分子进化类似情况的其他迹象。
